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Osbpl8 oxysterol binding protein-like 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314824, updated on 4-Jan-2025

Summary

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Official Symbol
Osbpl8provided by RGD
Official Full Name
oxysterol binding protein-like 8provided by RGD
Primary source
RGD:1561474
See related
EnsemblRapid:ENSRNOG00000026962 AllianceGenome:RGD:1561474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561474
Summary
Predicted to enable cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of sequestering of triglyceride; and positive regulation of D-glucose import. Predicted to act upstream of or within negative regulation of cell migration; positive regulation of signal transduction; and protein localization to nuclear pore. Predicted to be located in cortical endoplasmic reticulum and nuclear membrane. Predicted to be active in cytosol and membrane. Orthologous to human OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 284.0), Thymus (RPKM 187.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Osbpl8 in Genome Data Viewer
Location:
7q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (48483259..48636151)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (46596944..46749888)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (53878906..54030110)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093585 Neighboring gene uncharacterized LOC134479684 Neighboring gene U6 spliceosomal RNA Neighboring gene spindle apparatus coiled-coil protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120093586 Neighboring gene uncharacterized LOC134479686 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 8 Neighboring gene Bardet-Biedl syndrome 10 Neighboring gene uncharacterized LOC102548498 Neighboring gene uncharacterized LOC134479687

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Chung J, et al. Science, 2015 Jul 24. PMID 26206935, Free PMC Article
  2. Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143. Blumensatt M, et al. Cardiovasc Res, 2013 Nov 1. PMID 23812417
  3. Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity. Béaslas O, et al. Exp Cell Res, 2012 Sep 10. PMID 22683860
  4. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. Zhou Y, et al. PLoS One, 2012. PMID 23028956, Free PMC Article
  5. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Jordan SD, et al. Nat Cell Biol, 2011 Apr. PMID 21441927

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine transfer activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309455.2 → NP_001296384.1  oxysterol-binding protein-related protein 8

    See identical proteins and their annotated locations for NP_001296384.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JXN8, A0A8I6A2N1, A6IGF8
    Related
    ENSRNOP00000085965.2, ENSRNOT00000097311.2
    Conserved Domains (3) summary
    cd13286
    Location:141 → 270
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:148 → 264
    PH; PH domain
    pfam01237
    Location:406 → 744
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    48483259..48636151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263481.1 → XP_063119551.1  oxysterol-binding protein-related protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A2N1, A6IGG0
    Related
    ENSRNOP00000079217.1, ENSRNOT00000112719.2

  2. XM_017594846.3 → XP_017450335.1  oxysterol-binding protein-related protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADC9, A0A8I6GDH8
    Related
    ENSRNOP00000085930.1, ENSRNOT00000100604.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108093.1: Suppressed sequence

    Description
    NM_001108093.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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