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Mdm1 Mdm1 nuclear protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 314859, updated on 4-Jan-2025

Summary

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Official Symbol
Mdm1provided by RGD
Official Full Name
Mdm1 nuclear proteinprovided by RGD
Primary source
RGD:1561092
See related
EnsemblRapid:ENSRNOG00000007286 AllianceGenome:RGD:1561092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of centriole replication and retina development in camera-type eye. Predicted to be located in several cellular components, including cytosol; microtubule organizing center; and non-motile cilium. Orthologous to human MDM1 (Mdm1 nuclear protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 106.2), Testes (RPKM 102.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mdm1 in Genome Data Viewer
Location:
7q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (55615459..55651889)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (53729603..53766034)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (61165652..61200865)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351463 Neighboring gene uncharacterized LOC134479695 Neighboring gene uncharacterized LOC102551023 Neighboring gene interleukin 22 Neighboring gene small ubiquitin-related modifier 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. Hoh RA, et al. PLoS One, 2012. PMID 23300604, Free PMC Article
  2. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Chang B, et al. Hum Mol Genet, 2008 Dec 15. PMID 18805803, Free PMC Article
  3. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Van de Mark D, et al. Mol Biol Cell, 2015 Nov 1. PMID 26337392, Free PMC Article
  4. Mouse model resources for vision research. Won J, et al. J Ophthalmol, 2011. PMID 21052544, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of centriole replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in photoreceptor cell maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in retina development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear protein MDM1
Names
Mdm1 nuclear protein homolog
transformed mouse 3T3 cell double minute 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017459.2 → NP_001017459.2  nuclear protein MDM1

    See identical proteins and their annotated locations for NP_001017459.2

    Status: VALIDATED

    Source sequence(s)
    BC087101, CB544747, CV126474
    UniProtKB/Swiss-Prot
    Q5PQN4
    UniProtKB/TrEMBL
    A6IGU8
    Related
    ENSRNOP00000041359.4, ENSRNOT00000048765.7
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 554
    MDM1; Nuclear protein MDM1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    55615459..55651889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765400.4 → XP_008763622.1  nuclear protein MDM1 isoform X2

    UniProtKB/TrEMBL
    A6IGU8
    Conserved Domains (1) summary
    pfam15501
    Location:6 → 551
    MDM1; Nuclear protein MDM1

  2. XM_063263492.1 → XP_063119562.1  nuclear protein MDM1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2KB24, A6IGU8

  3. XM_063263496.1 → XP_063119566.1  nuclear protein MDM1 isoform X10

  4. XM_063263489.1 → XP_063119559.1  nuclear protein MDM1 isoform X2

    UniProtKB/TrEMBL
    A6IGU8

  5. XM_063263491.1 → XP_063119561.1  nuclear protein MDM1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2KB24, A6IGU8
    Related
    ENSRNOP00000075623.2, ENSRNOT00000087955.3

  6. XM_063263494.1 → XP_063119564.1  nuclear protein MDM1 isoform X8

    UniProtKB/TrEMBL
    A6IGU8

  7. XM_006241387.5 → XP_006241449.1  nuclear protein MDM1 isoform X3

    UniProtKB/TrEMBL
    A6IGU8
    Conserved Domains (1) summary
    pfam15501
    Location:5 → 550
    MDM1; Nuclear protein MDM1

  8. XM_063263493.1 → XP_063119563.1  nuclear protein MDM1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZUT4, A6IGU8

  9. XM_063263495.1 → XP_063119565.1  nuclear protein MDM1 isoform X9

    UniProtKB/TrEMBL
    A6IGU8

  10. XM_006241385.5 → XP_006241447.1  nuclear protein MDM1 isoform X1

    UniProtKB/TrEMBL
    A6IGU8
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 554
    MDM1; Nuclear protein MDM1

  11. XM_063263490.1 → XP_063119560.1  nuclear protein MDM1 isoform X5

    UniProtKB/TrEMBL
    A6IGU8
    Related
    ENSRNOP00000091573.1, ENSRNOT00000108196.2

  12. XM_006241388.5 → XP_006241450.1  nuclear protein MDM1 isoform X4

    See identical proteins and their annotated locations for XP_006241450.1

    UniProtKB/TrEMBL
    A6IGU6, A6IGU8
    Related
    ENSRNOP00000081317.2, ENSRNOT00000118906.2
    Conserved Domains (1) summary
    pfam15501
    Location:9 → 544
    MDM1; Nuclear protein MDM1

  13. XM_039079129.2 → XP_038935057.1  nuclear protein MDM1 isoform X11

    Conserved Domains (1) summary
    pfam15501
    Location:6 → 249
    MDM1; Nuclear protein MDM1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQN4.2 GenPept UniProtKB/Swiss-Prot:Q5PQN4

Gene LinkOut

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