U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AdamTS-B ADAM metallopeptidase with thrombospondin type 1 motif B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31490, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
AdamTS-Bprovided by FlyBase
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif Bprovided by FlyBase
Primary source
FLYBASE:FBgn0029791
Locus tag
Dmel_CG4096
See related
AllianceGenome:FB:FBgn0029791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4096; CT13580; Dmel\CG4096
Summary
Predicted to enable metalloendopeptidase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of imaginal disc-derived wing vein specification. Predicted to be active in extracellular matrix. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic epipharynx; embryonic hypopharynx; and presumptive wing vein. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and congenital heart disease. Orthologous to several human genes including ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) and ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AdamTS-B in Genome Data Viewer
Location:
5B1-5B1; 1-13 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5698557..5708633)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5592590..5602666)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42794 Neighboring gene uncharacterized protein Neighboring gene crossveinless Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 27 Neighboring gene uncharacterized protein Neighboring gene Integrator 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The extracellular protease AdamTS-B inhibits vein formation in the Drosophila wing. Pham MN, et al. Genesis, 2018 Dec. PMID 30296002
  2. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. Nicholson AC, et al. BMC Evol Biol, 2005 Feb 4. PMID 15693998, Free PMC Article
  3. Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling. Kim GW, et al. Sci Rep, 2016 Aug 18. PMID 27535473, Free PMC Article
  4. The secreted AdamTS-A metalloprotease is required for collective cell migration. Ismat A, et al. Development, 2013 May. PMID 23536567, Free PMC Article
  5. Molecular evolution of the Yap/Yorkie proto-oncogene and elucidation of its core transcriptional program. Ikmi A, et al. Mol Biol Evol, 2014 Jun. PMID 24509725, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ADAM metallopeptidase with thrombospondin type 1 motif B
Names
AdamTS-B-PB
AdamTS-B-PC
CG4096-PB
CG4096-PC
NP_001162678.1
NP_572247.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5698557..5708633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132019.3 → NP_572247.2  ADAM metallopeptidase with thrombospondin type 1 motif B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572247.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W493
    Conserved Domains (6) summary
    smart00209
    Location:614 → 666
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:314 → 518
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:315 → 521
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:78 → 194
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:773 → 886
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:558 → 602
    ADAM_CR; ADAM cysteine-rich

  2. NM_001169207.1 → NP_001162678.1  ADAM metallopeptidase with thrombospondin type 1 motif B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162678.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRL5
    Conserved Domains (5) summary
    smart00209
    Location:614 → 666
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:314 → 518
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:315 → 521
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:78 → 194
    Pep_M12B_propep; Reprolysin family propeptide
    cl15456
    Location:558 → 602
    ADAM_CR; ADAM cysteine-rich
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRL5 Q8MRL5
Q9W493 Q9W493

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous