Snx27 Sorting nexin 27 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Snx27provided by FlyBase
Official Full Name: Sorting nexin 27provided by FlyBase
Primary source: FLYBASE:FBgn0052758
Locus tag: Dmel_CG32758
See related: AllianceGenome:FB:FBgn0052758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11465; CG3130; CG3138; CG32758; Dmel\CG32758; DmSNX27; snx27
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5B2-5B3; 1-13 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5719374..5738031, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5613407..5632064, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sorting nexin 27

Names: CG32758-PA; CG32758-PC; CG32758-PD; Snx27-PA; Snx27-PC; Snx27-PD

NP_001259258.1

EC 3.4.24.-

NP_001284906.1

EC 3.4.24.-

NP_727023.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5719374..5738031 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297977.1 → NP_001284906.1 sorting nexin 27, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284906.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JIH1

Conserved Domains (4) summary

cd06886
Location:64 → 169

PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27

cd00992
Location:9 → 37

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13338
Location:327 → 427

FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

cd01777
Location:176 → 267

FERM_F1_SNX27; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 27 (SNX27)
NM_001272329.2 → NP_001259258.1 sorting nexin 27, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259258.1

Status: REVIEWED

UniProtKB/TrEMBL

F3YD98

Conserved Domains (4) summary

cd06886
Location:77 → 182

PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27

cd00992
Location:22 → 50

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13338
Location:340 → 440

FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

cl00155
Location:190 → 275

UBQ; Ubiquitin-like proteins
NM_167045.3 → NP_727023.1 sorting nexin 27, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727023.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W486

Related

FBpp0070808

Conserved Domains (4) summary

cd06886
Location:165 → 270

PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27

cd00992
Location:46 → 138

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13338
Location:428 → 528

FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

cl00155
Location:278 → 363

UBQ; Ubiquitin-like proteins