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IntS6 Integrator 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31496, updated on 9-Dec-2024

Summary

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Official Symbol
IntS6provided by FlyBase
Official Full Name
Integrator 6provided by FlyBase
Primary source
FLYBASE:FBgn0261383
Locus tag
Dmel_CG3125
See related
AllianceGenome:FB:FBgn0261383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3125; Dmel\CG3125; Int6; l(1)G0060
Summary
Involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS6 (integrator complex subunit 6) and INTS6L (integrator complex subunit 6 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See IntS6 in Genome Data Viewer
Location:
5B4-5B6; 1-13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5738663..5747254, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5632696..5641287, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif B Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 27 Neighboring gene uncharacterized protein Neighboring gene Regulator of telomere elongation helicase 1 Neighboring gene uncharacterized protein Neighboring gene lin-52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
  2. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  3. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  4. The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Liu S, et al. Cell Rep, 2023 Jan 31. PMID 36641752
  5. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events.
    Title: IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator 6
Names
CG3125-PA
CG3125-PB
CG3125-PC
CG3125-PD
CG3125-PE
IntS6-PA
IntS6-PB
IntS6-PC
IntS6-PD
IntS6-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5738663..5747254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272332.1 → NP_001259261.1  integrator 6, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259261.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960F1, Q9W485
    Conserved Domains (2) summary
    cd00198
    Location:4 → 147
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:1196 → 1257
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. NM_001272331.1 → NP_001259260.1  integrator 6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259260.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960F1, Q9W485
    Conserved Domains (2) summary
    cd00198
    Location:4 → 147
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:1196 → 1257
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. NM_132025.3 → NP_572253.2  integrator 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572253.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960F1, Q9W485
    Related
    FBpp0070806
    Conserved Domains (2) summary
    cd00198
    Location:4 → 147
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:1196 → 1257
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  4. NM_001272330.1 → NP_001259259.1  integrator 6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259259.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960F1, Q9W485
    Conserved Domains (2) summary
    cd00198
    Location:4 → 147
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:1196 → 1257
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  5. NM_167047.2 → NP_727026.1  integrator 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727026.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960F1, Q9W485
    Related
    FBpp0070807
    Conserved Domains (2) summary
    cd00198
    Location:4 → 147
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:1196 → 1257
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W485.2 Q9W485

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