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Apol3l1 apolipoprotein L3 like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315108, updated on 27-Nov-2024

Summary

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Official Symbol
Apol3l1provided by RGD
Official Full Name
apolipoprotein L3 like 1provided by RGD
Primary source
RGD:1306480
See related
EnsemblRapid:ENSRNOG00000042771 AllianceGenome:RGD:1306480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Apol3
Summary
Predicted to enable lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including APOL3 (apolipoprotein L3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 406.9), Liver (RPKM 398.9) and 9 other tissues See more
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Genomic context

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See Apol3l1 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111169307..111178306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109288725..109297728)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (118685022..118694016)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein L11a Neighboring gene uncharacterized LOC134479936 Neighboring gene uncharacterized LOC102552424 Neighboring gene apolipoprotein L7b like 1 Neighboring gene apolipoprotein L2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apolipoprotein L, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013175.3 → NP_001013193.1  apolipoprotein L, 3

    See identical proteins and their annotated locations for NP_001013193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSG3, Q5U1W1
    Related
    ENSRNOP00000075710.1, ENSRNOT00000089135.3
    Conserved Domains (1) summary
    pfam05461
    Location:35 → 332
    ApoL; Apolipoprotein L

  2. NM_001277359.3 → NP_001264288.1  apolipoprotein L, 3

    See identical proteins and their annotated locations for NP_001264288.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSG3, Q5U1W1
    Conserved Domains (1) summary
    pfam05461
    Location:35 → 332
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    111169307..111178306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079252.2 → XP_038935180.1  apolipoprotein L, 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AP14
    Conserved Domains (1) summary
    pfam05461
    Location:3 → 286
    ApoL; Apolipoprotein L
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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