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Ccnt1 cyclin T1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315291, updated on 27-Nov-2024

Summary

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Symbol
Ccnt1provided by RGD
Full Name
cyclin T1provided by RGD
Primary source
RGD:1311151
See related
EnsemblRapid:ENSRNOG00000053054 AllianceGenome:RGD:1311151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; enzyme binding activity; and nucleic acid binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of P-TEFb complex. Predicted to be active in nucleus. Orthologous to human CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 121.7), Spleen (RPKM 117.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccnt1 in Genome Data Viewer
Location:
7q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131566176..131596988, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129687146..129718080, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140215052..140245958, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 34 Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene sperm microtubule inner protein 11 Neighboring gene cystatin C, pseudogene 1 Neighboring gene adenylate cyclase 6 Neighboring gene tubulin, alpha 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. Zhou JY, et al. Fitoterapia, 2011 Mar. PMID 20828602
  2. The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2. Nojima M, et al. J Mol Biol, 2008 Oct 3. PMID 18662700, Free PMC Article
  3. Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. Sano M, et al. EMBO J, 2004 Sep 1. PMID 15297879, Free PMC Article
  4. NUCKS1, a novel Tat coactivator, plays a crucial role in HIV-1 replication by increasing Tat-mediated viral transcription on the HIV-1 LTR promoter. Kim HY, et al. Retrovirology, 2014 Aug 13. PMID 25116364, Free PMC Article
  5. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Young TM, et al. Mol Cell Biol, 2003 Sep. PMID 12944466, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of P-TEFb complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin/CDK positive transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-T1
Names
cyclin-T1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412623.1 → NP_001399552.1  cyclin-T1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JXM2
    Related
    ENSRNOP00000106394.1, ENSRNOT00000129768.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131566176..131596988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263670.1 → XP_063119740.1  cyclin-T1 isoform X1

  2. XM_063263671.1 → XP_063119741.1  cyclin-T1 isoform X2

RNA

  1. XR_593621.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108110.1: Suppressed sequence

    Description
    NM_001108110.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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