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Nckap5l NCK-associated protein 5-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 315297, updated on 27-Nov-2024

Summary

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Official Symbol
Nckap5lprovided by RGD
Official Full Name
NCK-associated protein 5-likeprovided by RGD
Primary source
RGD:1561571
See related
EnsemblRapid:ENSRNOG00000056678 AllianceGenome:RGD:1561571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561571
Summary
Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be located in centrosome. Predicted to be active in microtubule plus-end. Orthologous to human NCKAP5L (NCK associated protein 5 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 23.3), Lung (RPKM 21.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nckap5l in Genome Data Viewer
Location:
7q36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132433569..132470638, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130553683..130591886, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141081943..141093924, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene formin-like 3 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene uncharacterized LOC134479570 Neighboring gene uncharacterized LOC102546778 Neighboring gene BCDIN3 domain containing RNA methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. Mori Y, et al. PLoS One, 2015. PMID 26485573, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nck-associated protein 5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271369.4 → NP_001258298.1  nck-associated protein 5-like

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K5W1
    Conserved Domains (4) summary
    PHA03247
    Location:435 → 914
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:203 → 531
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:873 → 1173
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
    cl40461
    Location:58 → 134
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132433569..132470638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079326.2 → XP_038935254.1  nck-associated protein 5-like isoform X1

    Related
    ENSRNOP00000073580.3, ENSRNOT00000081434.3
    Conserved Domains (4) summary
    PHA03247
    Location:515 → 994
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:283 → 611
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:953 → 1253
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
    cl40461
    Location:138 → 214
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  2. XM_039079328.2 → XP_038935256.1  nck-associated protein 5-like isoform X2

    UniProtKB/TrEMBL
    A0A0G2K5W1
    Conserved Domains (4) summary
    PHA03247
    Location:435 → 914
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:203 → 531
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15246
    Location:873 → 1173
    NCKAP5; Nck-associated protein 5, Peripheral clock protein
    cl40461
    Location:58 → 134
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  3. XM_063263672.1 → XP_063119742.1  nck-associated protein 5-like isoform X2

    UniProtKB/TrEMBL
    A0A0G2K5W1
    Related
    ENSRNOP00000101031.1, ENSRNOT00000162472.1
Nucleotide Protein Strain
Heading Accession and Version

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