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Csrnp2 cysteine and serine rich nuclear protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315308, updated on 27-Nov-2024

Summary

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Official Symbol
Csrnp2provided by RGD
Official Full Name
cysteine and serine rich nuclear protein 2provided by RGD
Primary source
RGD:1308916
See related
EnsemblRapid:ENSRNOG00000019653 AllianceGenome:RGD:1308916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Csnrp2; RGD1308916
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; phosphatase binding activity; and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human CSRNP2 (cysteine and serine rich nuclear protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 57.4), Heart (RPKM 47.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csrnp2 in Genome Data Viewer
Location:
7q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133473027..133488868, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131594232..131610075, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142116335..142132173, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thiol methyltransferase 1A Neighboring gene uncharacterized LOC134479577 Neighboring gene HIG1 hypoxia inducible domain family, member 1C Neighboring gene solute carrier family 11 member 2 Neighboring gene uncharacterized LOC120093735 Neighboring gene LETM1 domain containing 1 Neighboring gene transcription factor CP2 Neighboring gene uncharacterized LOC120093736 Neighboring gene POU class 6 homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
  2. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine/serine-rich nuclear protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108113.1 → NP_001101583.1  cysteine/serine-rich nuclear protein 2

    See identical proteins and their annotated locations for NP_001101583.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474035
    UniProtKB/TrEMBL
    A6KCK1, D4A1W4
    Related
    ENSRNOP00000026613.4, ENSRNOT00000026613.6
    Conserved Domains (1) summary
    pfam16019
    Location:62 → 279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133473027..133488868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079340.2 → XP_038935268.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    A6KCK1, D4A1W4
    Conserved Domains (1) summary
    pfam16019
    Location:62 → 279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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