U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Espl1 extra spindle pole bodies like 1, separase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315330, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Symbol
Espl1provided by RGD
Full Name
extra spindle pole bodies like 1, separaseprovided by RGD
Primary source
RGD:1306266
See related
EnsemblRapid:ENSRNOG00000012835 AllianceGenome:RGD:1306266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in meiotic chromosome separation. Predicted to act upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 55.3), Testes (RPKM 49.5) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Espl1 in Genome Data Viewer
Location:
7q36
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135302460..135329570)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133424027..133450984)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143896890..143923868)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479581 Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene uncharacterized LOC134479583 Neighboring gene prefoldin subunit 5 Neighboring gene MYG1 exonuclease

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Processing, localization, and requirement of human separase for normal anaphase progression. Chestukhin A, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12672959, Free PMC Article
  2. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. Wirth KG, et al. J Cell Biol, 2006 Mar 13. PMID 16533945, Free PMC Article
  3. Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. Kudo NR, et al. J Cell Sci, 2009 Aug 1. PMID 19625504, Free PMC Article
  4. Wapl is an essential regulator of chromatin structure and chromosome segregation. Tedeschi A, et al. Nature, 2013 Sep 26. PMID 23975099, Free PMC Article
  5. The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Terret ME, et al. Curr Biol, 2003 Oct 14. PMID 14561405

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homologous chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
separin
Names
extra spindle pole bodies 1, separase
extra spindle pole bodies homolog 1
extra spindle poles like 1
separin-like
NP_001164073.1
XP_006242522.1
XP_038935274.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170602.1 → NP_001164073.1  separin

    See identical proteins and their annotated locations for NP_001164073.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KCU2, D3ZDT7
    Related
    ENSRNOP00000017314.6, ENSRNOT00000017314.8
    Conserved Domains (1) summary
    pfam03568
    Location:1709 → 2056
    Peptidase_C50; Peptidase family C50

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135302460..135329570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242460.5 → XP_006242522.1  separin isoform X1

    See identical proteins and their annotated locations for XP_006242522.1

    UniProtKB/TrEMBL
    A6KCU2, D3ZDT7
    Conserved Domains (1) summary
    pfam03568
    Location:1709 → 2056
    Peptidase_C50; Peptidase family C50

  2. XM_039079346.2 → XP_038935274.1  separin isoform X1

    UniProtKB/TrEMBL
    A6KCU2, D3ZDT7
    Conserved Domains (1) summary
    pfam03568
    Location:1709 → 2056
    Peptidase_C50; Peptidase family C50
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools