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Cep126 centrosomal protein 126 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315409, updated on 4-Jan-2025

Summary

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Official Symbol
Cep126provided by RGD
Official Full Name
centrosomal protein 126provided by RGD
Primary source
RGD:1563556
See related
EnsemblRapid:ENSRNOG00000021839 AllianceGenome:RGD:1563556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563556
Summary
Predicted to be involved in cilium assembly; cytoplasmic microtubule organization; and mitotic spindle organization. Predicted to be active in centrosome; ciliary base; and midbody. Orthologous to human CEP126 (centrosomal protein 126). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 48.1), Brain (RPKM 29.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep126 in Genome Data Viewer
Location:
8q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (13485211..13552711, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (5200576..5267740, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (6237838..6305127, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Yes1 associated transcriptional regulator Neighboring gene cilia and flagella associated protein 300 Neighboring gene PMS1 protein homolog 1-like Neighboring gene PMS1 protein homolog 1 pseudogene Neighboring gene 60S ribosomal protein L13-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation. Bonavita R, et al. Biol Cell, 2014 Aug. PMID 24867236, Free PMC Article
  2. From midbody protein-protein interaction network construction to novel regulators in cytokinesis. Chen TC, et al. J Proteome Res, 2009 Nov. PMID 19799413
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 126 kDa
Names
centrosomal protein 126kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427808.1 → NP_001414737.1  centrosomal protein of 126 kDa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6JN52
    Related
    ENSRNOP00000111909.1, ENSRNOT00000164441.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    13485211..13552711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595957.3 → XP_017451446.1  centrosomal protein of 126 kDa isoform X3

    UniProtKB/TrEMBL
    A6JN52
    Related
    ENSRNOP00000104656.1, ENSRNOT00000129079.1

  2. XM_006242509.5 → XP_006242571.1  centrosomal protein of 126 kDa isoform X4

    See identical proteins and their annotated locations for XP_006242571.1

    UniProtKB/TrEMBL
    A6JN52
    Related
    ENSRNOP00000109418.1, ENSRNOT00000146889.1
    Conserved Domains (2) summary
    pfam13863
    Location:44 → 115
    DUF4200; Domain of unknown function (DUF4200)
    pfam15352
    Location:100 → 1050
    K1377; Susceptibility to monomelic amyotrophy

  3. XM_006242504.5 → XP_006242566.1  centrosomal protein of 126 kDa isoform X1

    See identical proteins and their annotated locations for XP_006242566.1

    UniProtKB/TrEMBL
    A0A8I6AET0, A6JN52
    Related
    ENSRNOP00000090687.1, ENSRNOT00000105514.2
    Conserved Domains (2) summary
    pfam13863
    Location:44 → 115
    DUF4200; Domain of unknown function (DUF4200)
    pfam15352
    Location:100 → 1050
    K1377; Susceptibility to monomelic amyotrophy

  4. XM_006242510.5 → XP_006242572.1  centrosomal protein of 126 kDa isoform X5

    See identical proteins and their annotated locations for XP_006242572.1

    UniProtKB/TrEMBL
    A6JN52, D3ZT87
    Related
    ENSRNOP00000030837.7, ENSRNOT00000029887.8
    Conserved Domains (2) summary
    pfam13863
    Location:44 → 115
    DUF4200; Domain of unknown function (DUF4200)
    pfam15352
    Location:100 → 1050
    K1377; Susceptibility to monomelic amyotrophy

  5. XM_006242505.5 → XP_006242567.1  centrosomal protein of 126 kDa isoform X2

    See identical proteins and their annotated locations for XP_006242567.1

    UniProtKB/TrEMBL
    A0A8I6AUH6, A6JN52
    Related
    ENSRNOP00000095996.1, ENSRNOT00000097345.2
    Conserved Domains (2) summary
    pfam13863
    Location:44 → 115
    DUF4200; Domain of unknown function (DUF4200)
    pfam15352
    Location:100 → 1050
    K1377; Susceptibility to monomelic amyotrophy

  6. XM_039082221.2 → XP_038938149.1  centrosomal protein of 126 kDa isoform X6

    UniProtKB/TrEMBL
    A6JN52
    Conserved Domains (1) summary
    pfam15352
    Location:1 → 860
    K1377; Susceptibility to monomelic amyotrophy

  7. XM_039082222.2 → XP_038938150.1  centrosomal protein of 126 kDa isoform X6

    UniProtKB/TrEMBL
    A6JN52
    Conserved Domains (1) summary
    pfam15352
    Location:1 → 860
    K1377; Susceptibility to monomelic amyotrophy

  8. XM_039082223.2 → XP_038938151.1  centrosomal protein of 126 kDa isoform X7

    UniProtKB/TrEMBL
    A6JN52
    Conserved Domains (2) summary
    pfam17380
    Location:46 → 145
    DUF5401; Family of unknown function (DUF5401)
    pfam15352
    Location:100 → 925
    K1377; Susceptibility to monomelic amyotrophy

RNA

  1. XR_001839243.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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