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Odad3 outer dynein arm docking complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315465, updated on 4-Jan-2025

Summary

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Official Symbol
Odad3provided by RGD
Official Full Name
outer dynein arm docking complex subunit 3provided by RGD
Primary source
RGD:1310048
See related
EnsemblRapid:ENSRNOG00000013263 AllianceGenome:RGD:1310048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc151; RGD1310048
Summary
Predicted to be involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Predicted to act upstream of or within several processes, including determination of heart left/right asymmetry; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Predicted to be located in axoneme and centriole. Predicted to be active in ciliary basal body; ciliary rootlet; and ciliary tip. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 65.7), Adrenal (RPKM 9.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Odad3 in Genome Data Viewer
Location:
8q13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28796909..28810587, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20520898..20534499, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23000912..23014707, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene erythropoietin receptor Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene uncharacterized LOC134480147 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene ELAV like RNA binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Jerber J, et al. Hum Mol Genet, 2014 Feb 1. PMID 24067530
  2. CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. Hjeij R, et al. Am J Hum Genet, 2014 Sep 4. PMID 25192045, Free PMC Article
  3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebrospinal fluid circulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of heart left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary rootlet IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
outer dynein arm-docking complex subunit 3
Names
coiled-coil domain containing 151
coiled-coil domain-containing protein 151

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309457.1 → NP_001296386.1  outer dynein arm-docking complex subunit 3

    See identical proteins and their annotated locations for NP_001296386.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6JNX0, D4ABL9
    Related
    ENSRNOP00000017820.7, ENSRNOT00000017820.8
    Conserved Domains (1) summary
    COG1196
    Location:63 → 450
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28796909..28810587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265339.1 → XP_063121409.1  outer dynein arm-docking complex subunit 3 isoform X2

    UniProtKB/TrEMBL
    D4ABL9
    Related
    ENSRNOP00000098818.1, ENSRNOT00000164436.1

  2. XM_063265340.1 → XP_063121410.1  outer dynein arm-docking complex subunit 3 isoform X3

    UniProtKB/TrEMBL
    D4ABL9

  3. XM_063265338.1 → XP_063121408.1  outer dynein arm-docking complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    D4ABL9

  4. XM_063265341.1 → XP_063121411.1  outer dynein arm-docking complex subunit 3 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108130.1: Suppressed sequence

    Description
    NM_001108130.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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