wuho wuho [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wuhoprovided by FlyBase
Official Full Name: wuhoprovided by FlyBase
Primary source: FLYBASE:FBgn0029857
Locus tag: Dmel_CG15897
See related: AllianceGenome:FB:FBgn0029857
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15897; Dmel\CG15897; wh; Wuho
Summary: Involved in oogenesis and spermatogenesis. Located in female germ cell nucleus and male germ cell nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6288100..6289562)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6182133..6183595)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Wh is a regulator of Mei-p26 in Drosophila germ cells
Title: WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila.
CG15897, here named wuho (wh) contains 5 WD40 repeats; has a critical function in cellular differentiation for germline cells during gametogenesis
Title: A new Drosophila gene wh (wuho) with WD40 repeats is essential for spermatogenesis and has maximal expression in hub cells.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA (m7G46) methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain