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Dpp8 dipeptidylpeptidase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315758, updated on 27-Nov-2024

Summary

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Official Symbol
Dpp8provided by RGD
Official Full Name
dipeptidylpeptidase 8provided by RGD
Primary source
RGD:1310901
See related
EnsemblRapid:ENSRNOG00000019105 AllianceGenome:RGD:1310901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 407.7), Kidney (RPKM 261.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dpp8 in Genome Data Viewer
Location:
8q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74445815..74501017)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65550620..65605828)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70521782..70576180)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 14 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Harstad EB, et al. Regul Pept, 2013 Sep 10. PMID 23850796
  2. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. Dubois V, et al. J Histochem Cytochem, 2009 Jun. PMID 19188489, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DPP8 and DPP9 may act similarly across tissues, and that their actions might in part overlap with DPP4.
    Title: DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
  2. We showed the expression of DPP8 and DPP9 in the testis, epididymis, and sperm.
    Title: Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 8
NP_001381020.1
NP_001381021.1
NP_001381022.1
XP_006243316.1
XP_006243318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394091.1 → NP_001381020.1  dipeptidyl peptidase 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J5D8, D3ZHQ1
    Related
    ENSRNOP00000084987.2, ENSRNOT00000111343.2
    Conserved Domains (2) summary
    pfam00326
    Location:680 → 885
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:169 → 589
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. NM_001394092.1 → NP_001381021.1  dipeptidyl peptidase 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J5D8, D3ZHQ1
    Conserved Domains (2) summary
    pfam00326
    Location:680 → 885
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:169 → 589
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  3. NM_001394093.1 → NP_001381022.1  dipeptidyl peptidase 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Conserved Domains (2) summary
    pfam00326
    Location:671 → 876
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:160 → 580
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RNA

  1. NR_172080.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    74445815..74501017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243256.5 → XP_006243318.1  dipeptidyl peptidase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A305, A6J5D9
    Conserved Domains (2) summary
    pfam00930
    Location:169 → 589
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:680 → 716
    Abhydrolase; alpha/beta hydrolases

  2. XM_006243254.3 → XP_006243316.1  dipeptidyl peptidase 8 isoform X1

    See identical proteins and their annotated locations for XP_006243316.1

    UniProtKB/TrEMBL
    A6J5D8, D3ZHQ1
    Conserved Domains (2) summary
    pfam00326
    Location:680 → 885
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:169 → 589
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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