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CG3842 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31576, updated on 4-Jan-2025

Summary

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Official Symbol
CG3842provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0029866
Locus tag
Dmel_CG3842
See related
AllianceGenome:FB:FBgn0029866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3842; lincRNA.959
Summary
Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinal metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic anal pad; embryonic dorsal epidermis; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to human RDH11 (retinol dehydrogenase 11) and RDH12 (retinol dehydrogenase 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG3842 in Genome Data Viewer
Location:
5F2-5F2; 1-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6337762..6343731)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6231795..6237764)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B16.6 subunit Neighboring gene knockdown

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster. Belyaeva OV, et al. Biochim Biophys Acta, 2009 Oct. PMID 19520149, Free PMC Article
  2. Transcript level is a key factor affecting RNAi efficiency. Chen J, et al. Pestic Biochem Physiol, 2021 Jul. PMID 34119217
  3. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article
  4. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
  5. Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila. Pedra JH, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15118106, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG3842-PA
CG3842-PB
CG3842-PC
CG3842-PD
NP_001259270.1
NP_001259271.1
NP_572316.1
NP_996356.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6337762..6343731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272342.2 → NP_001259271.1  uncharacterized protein Dmel_CG3842, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNM5, Q9W404
    Conserved Domains (2) summary
    COG1028
    Location:71 → 319
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl21454
    Location:74 → 347
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001272341.1 → NP_001259270.1  uncharacterized protein Dmel_CG3842, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNM5, Q9W404
    Conserved Domains (2) summary
    COG1028
    Location:71 → 319
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl21454
    Location:74 → 347
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_132088.3 → NP_572316.1  uncharacterized protein Dmel_CG3842, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572316.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNM5, Q9W404
    Related
    FBpp0070868
    Conserved Domains (2) summary
    COG1028
    Location:71 → 319
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl21454
    Location:74 → 347
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. NM_206633.3 → NP_996356.1  uncharacterized protein Dmel_CG3842, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNM5, Q9W404
    Conserved Domains (2) summary
    COG1028
    Location:71 → 319
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl21454
    Location:74 → 347
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W404 Q9W404

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