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Mtfmt mitochondrial methionyl-tRNA formyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315763, updated on 4-Jan-2025

Summary

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Official Symbol
Mtfmtprovided by RGD
Official Full Name
mitochondrial methionyl-tRNA formyltransferaseprovided by RGD
Primary source
RGD:1309462
See related
EnsemblRapid:ENSRNOG00000014602 AllianceGenome:RGD:1309462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309462
Summary
Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 88.1), Adrenal (RPKM 73.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtfmt in Genome Data Viewer
Location:
8q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74848936..74866987)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65953787..65971841)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70952209..70986393)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RAS-like, family 12 Neighboring gene SLC51 subunit beta Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene ankyrin repeat and death domain containing 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC95129

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables methionyl-tRNA formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionyl-tRNA formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionyl-tRNA formyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methionyl-tRNA formyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
methionyl-tRNA formyltransferase, mitochondrial
NP_001009697.1
XP_038937434.1
XP_038937435.1
XP_063121592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009697.1 → NP_001009697.1  methionyl-tRNA formyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001009697.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088470
    UniProtKB/Swiss-Prot
    Q5I0C5
    UniProtKB/TrEMBL
    A0A8L2QA74, A6J5F4
    Related
    ENSRNOP00000019671.4, ENSRNOT00000019671.7
    Conserved Domains (1) summary
    TIGR00460
    Location:44 → 353
    fmt; methionyl-tRNA formyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    74848936..74866987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265522.1 → XP_063121592.1  methionyl-tRNA formyltransferase, mitochondrial isoform X2

  2. XM_039081506.1 → XP_038937434.1  methionyl-tRNA formyltransferase, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR00460
    Location:9 → 226
    fmt; methionyl-tRNA formyltransferase

  3. XM_039081507.2 → XP_038937435.1  methionyl-tRNA formyltransferase, mitochondrial isoform X3

    Conserved Domains (2) summary
    COG0223
    Location:6 → 175
    Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
    cl00395
    Location:6 → 70
    FMT_core; Formyltransferase, catalytic core domain

RNA

  1. XR_005487822.2 RNA Sequence

  2. XR_005487823.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0C5.1 GenPept UniProtKB/Swiss-Prot:Q5I0C5

Gene LinkOut

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Chemical Information
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