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Trip4 thyroid hormone receptor interactor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315769, updated on 27-Nov-2024

Summary

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Official Symbol
Trip4provided by RGD
Official Full Name
thyroid hormone receptor interactor 4provided by RGD
Primary source
RGD:1306838
See related
EnsemblRapid:ENSRNOG00000016121 AllianceGenome:RGD:1306838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including estrogen receptor signaling pathway; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including centrosome; neuromuscular junction; and nuclear body. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 44.0), Thymus (RPKM 43.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trip4 in Genome Data Viewer
Location:
8q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75248352..75334802, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66351861..66439679, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71369121..71533281, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease. Davignon L, et al. Hum Mol Genet, 2016 Apr 15. PMID 27008887
  2. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
  3. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Kim HJ, et al. Mol Cell Biol, 1999 Sep. PMID 10454579, Free PMC Article
  4. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
  5. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Yoo HM, et al. Mol Cell, 2014 Oct 23. PMID 25219498

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188852

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RQC-trigger complex IEA
Inferred from Electronic Annotation
more info
  
part_of activating signal cointegrator 1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134981.2 → NP_001128453.1  activating signal cointegrator 1

    See identical proteins and their annotated locations for NP_001128453.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AG66, B5DEP5, F7FN66
    Related
    ENSRNOP00000021863.4, ENSRNOT00000021863.9
    Conserved Domains (2) summary
    cd06554
    Location:434 → 547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:168 → 216
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  2. NM_001433738.1 → NP_001420667.1  activating signal cointegrator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001433739.1 → NP_001420668.1  activating signal cointegrator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  4. NM_001433740.1 → NP_001420669.1  activating signal cointegrator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  5. NM_001433741.1 → NP_001420670.1  activating signal cointegrator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  6. NM_001433742.1 → NP_001420671.1  activating signal cointegrator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    75248352..75334802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766281.4 → XP_008764503.3  activating signal cointegrator 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0P5, A0A8I6A5V7
    Related
    ENSRNOP00000071531.2, ENSRNOT00000085745.3
    Conserved Domains (2) summary
    cd06554
    Location:535 → 648
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:269 → 317
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

  2. XM_039081508.2 → XP_038937436.1  activating signal cointegrator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5V7, A0A8I6AWC1
    Related
    ENSRNOP00000097416.1, ENSRNOT00000094012.2
    Conserved Domains (2) summary
    cd06554
    Location:552 → 665
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:286 → 334
    zf-C2HC5; Putative zinc finger motif, C2HC5-type

RNA

  1. XR_010053965.1 RNA Sequence

  2. XR_005487825.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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