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Tln2 talin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315776, updated on 27-Nov-2024

Summary

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Symbol
Tln2provided by RGD
Full Name
talin 2provided by RGD
Primary source
RGD:1565416
See related
EnsemblRapid:ENSRNOG00000018373 AllianceGenome:RGD:1565416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565416
Summary
Predicted to enable integrin binding activity. Predicted to be involved in cell-cell adhesion and presynaptic actin cytoskeleton organization. Is active in presynapse. Orthologous to human TLN2 (talin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 178.4), Heart (RPKM 100.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tln2 in Genome Data Viewer
Location:
8q24
Exon count:
63
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76712112..77133361, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67830920..68252240, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (73009980..73441536, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tropomyosin 1 Neighboring gene microRNA 190 Neighboring gene U6 spliceosomal RNA Neighboring gene TATA-box binding protein associated factor 12, pseudogene 1 Neighboring gene uncharacterized LOC100911360

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Di Paolo G, et al. Nature, 2002 Nov 7. PMID 12422219
  2. Talins and kindlins: partners in integrin-mediated adhesion. Calderwood DA, et al. Nat Rev Mol Cell Biol, 2013 Aug. PMID 23860236, Free PMC Article
  3. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. Balamuth F, et al. J Immunol, 2004 May 15. PMID 15128768
  4. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Zhang JQ, et al. Biochemistry, 2001 Dec 11. PMID 11732910
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
talin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419941.1 → NP_001406870.1  talin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000099929.1, ENSRNOT00000121208.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    76712112..77133361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265537.1 → XP_063121607.1  talin-2 isoform X4

    UniProtKB/TrEMBL
    D4A3B0
    Related
    ENSRNOP00000061714.4, ENSRNOT00000064613.6

  2. XM_017596083.2 → XP_017451572.1  talin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6H9
    Conserved Domains (10) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:92 → 318
    B41; Band 4.1 homologues
    smart00307
    Location:2299 → 2509
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:208 → 318
    FERM_M; FERM central domain
    pfam08913
    Location:1852 → 1936
    VBS; Vinculin Binding Site
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    pfam09379
    Location:94 → 190
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:6 → 87
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  3. XM_017596080.2 → XP_017451569.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUI0, A0A8I5Y6H9
    Related
    ENSRNOP00000069105.2, ENSRNOT00000081450.3
    Conserved Domains (10) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:92 → 318
    B41; Band 4.1 homologues
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:208 → 318
    FERM_M; FERM central domain
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    pfam09379
    Location:94 → 190
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:6 → 87
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  4. XM_063265536.1 → XP_063121606.1  talin-2 isoform X2

  5. XM_063265535.1 → XP_063121605.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUI0

  6. XM_017596082.2 → XP_017451571.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUI0, A0A8I5Y6H9
    Conserved Domains (10) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:92 → 318
    B41; Band 4.1 homologues
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:208 → 318
    FERM_M; FERM central domain
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    pfam09379
    Location:94 → 190
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:6 → 87
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  7. XM_063265534.1 → XP_063121604.1  talin-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUI0

  8. XM_008766402.4 → XP_008764624.1  talin-2 isoform X1

    See identical proteins and their annotated locations for XP_008764624.1

    UniProtKB/TrEMBL
    A0A0G2JUI0, A0A8I5Y6H9
    Related
    ENSRNOP00000024885.8, ENSRNOT00000024885.9
    Conserved Domains (10) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:92 → 318
    B41; Band 4.1 homologues
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:208 → 318
    FERM_M; FERM central domain
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    pfam09379
    Location:94 → 190
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:6 → 87
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  9. XM_008766403.4 → XP_008764625.1  talin-2 isoform X1

    See identical proteins and their annotated locations for XP_008764625.1

    UniProtKB/TrEMBL
    A0A0G2JUI0, A0A8I5Y6H9
    Conserved Domains (10) summary
    cd12150
    Location:1658 → 1829
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:92 → 318
    B41; Band 4.1 homologues
    smart00307
    Location:2339 → 2549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:314 → 405
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:208 → 318
    FERM_M; FERM central domain
    pfam08913
    Location:1852 → 1976
    VBS; Vinculin Binding Site
    pfam09141
    Location:496 → 657
    Talin_middle; Talin, middle domain
    pfam09379
    Location:94 → 190
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:6 → 87
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:691 → 767
    I_LWEQ; I/LWEQ domain

  10. XM_063265538.1 → XP_063121608.1  talin-2 isoform X5

  11. XM_063265539.1 → XP_063121609.1  talin-2 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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