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Dop1a DOP1 leucine zipper like protein A [ Rattus norvegicus (Norway rat) ]

Gene ID: 315864, updated on 27-Nov-2024

Summary

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Official Symbol
Dop1aprovided by RGD
Official Full Name
DOP1 leucine zipper like protein Aprovided by RGD
Primary source
RGD:1305534
See related
EnsemblRapid:ENSRNOG00000022847 AllianceGenome:RGD:1305534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dopey1; RGD1305534
Summary
Predicted to be involved in Golgi to endosome transport. Located in Golgi-associated vesicle. Orthologous to human DOP1A (DOP1 leucine zipper like protein A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 168.0), Brain (RPKM 124.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dop1a in Genome Data Viewer
Location:
8q31
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96295302..96397951)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (87415266..87517935)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94122733..94225131)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480084 Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The VF rat with abnormal myelinogenesis has a mutation in Dopey1. Tanaka M, et al. Glia, 2014 Sep. PMID 24863653
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein dopey-1
Names
dopey family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427274.1 → NP_001414203.1  protein dopey-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    Related
    ENSRNOP00000083794.2, ENSRNOT00000114743.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    96295302..96397951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596105.3 → XP_017451594.1  protein dopey-1 isoform X1

    UniProtKB/TrEMBL
    D4A0Y2

  2. XM_017596108.3 → XP_017451597.1  protein dopey-1 isoform X3

    UniProtKB/TrEMBL
    D4A0Y2
    Related
    ENSRNOP00000014783.8, ENSRNOT00000014783.10

  3. XM_017596107.3 → XP_017451596.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    D4A0Y2

  4. XM_039082549.2 → XP_038938477.1  protein dopey-1 isoform X5

    UniProtKB/TrEMBL
    D4A0Y2
    Related
    ENSRNOP00000102517.1, ENSRNOT00000143181.1
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2078 → 2314
    Dopey_N; Dopey, N-terminal

  5. XM_006243503.5 → XP_006243565.1  protein dopey-1 isoform X4

    See identical proteins and their annotated locations for XP_006243565.1

    UniProtKB/TrEMBL
    A0A8I6A0N6, D4A0Y2
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 300
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2079 → 2315
    Dopey_N; Dopey, N-terminal

  6. XM_063265561.1 → XP_063121631.1  protein dopey-1 isoform X2

  7. XM_017596106.3 → XP_017451595.1  protein dopey-1 isoform X1

    UniProtKB/TrEMBL
    D4A0Y2

  8. XM_039082550.2 → XP_038938478.1  protein dopey-1 isoform X6

    Conserved Domains (1) summary
    cl04407
    Location:1525 → 1761
    Dopey_N; Dopey, N-terminal

RNA

  1. XR_005488357.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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