Tbc1d8b TBC1 domain family member 8B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbc1d8bprovided by RGD
Official Full Name: TBC1 domain family member 8Bprovided by RGD
Primary source: RGD:1563084
See related: EnsemblRapid:ENSRNOG00000054011 AllianceGenome:RGD:1563084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563084
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in glomerular filtration and vesicle-mediated transport. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in nephrotic syndrome type 20. Orthologous to human TBC1D8B (TBC1 domain family member 8B). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 108.9), Liver (RPKM 59.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (108107796..108195744)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (103319181..103407137)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (110894831..110983269)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glomerular filtration	IBA Inferred from Biological aspect of Ancestor more info
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TBC1 domain family member 8B

Names: TBC1 domain family, member 8B (with GRAM domain)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401137.1 → NP_001388066.1 TBC1 domain family member 8B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K9M5, A0A8I6A9P8

Related

ENSRNOP00000075054.2, ENSRNOT00000080072.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

108107796..108195744

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100636.2 → XP_038956564.1 TBC1 domain family member 8B isoform X1

Conserved Domains (3) summary

smart00164
Location:485 → 693

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

cd13352
Location:296 → 388

PH-GRAM2_TBC1D8B; TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2

cd13350
Location:156 → 254

PH-GRAM1_TBC1D8B; TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
XM_039100637.2 → XP_038956565.1 TBC1 domain family member 8B isoform X3

Conserved Domains (3) summary

COG5210
Location:402 → 572

COG5210; GTPase-activating protein [General function prediction only]

cd13352
Location:296 → 388

PH-GRAM2_TBC1D8B; TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2

cd13350
Location:156 → 254

PH-GRAM1_TBC1D8B; TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
XM_063280009.1 → XP_063136079.1 TBC1 domain family member 8B isoform X2