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Pat1 Protein interacting with APP tail-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31593, updated on 9-Dec-2024

Summary

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Official Symbol
Pat1provided by FlyBase
Official Full Name
Protein interacting with APP tail-1provided by FlyBase
Primary source
FLYBASE:FBgn0029878
Locus tag
Dmel_CG10695
See related
AllianceGenome:FB:FBgn0029878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10695; Dmel\CG10695; pat1; PAT1
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in pole plasm oskar mRNA localization and regulation of microtubule-based movement. Part of kinesin complex. Is expressed in adult brain; organism; and ovary. Orthologous to human APPBP2 (amyloid beta precursor protein binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pat1 in Genome Data Viewer
Location:
6C1-6C1; 1-18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6590776..6596954)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6484809..6490987)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43832 Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 7 Neighboring gene pickled eggs Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte. Russell SL, et al. PLoS Pathog, 2018 Aug. PMID 30110391, Free PMC Article
  2. Klar ensures thermal robustness of oskar localization by restraining RNP motility. Gaspar I, et al. J Cell Biol, 2014 Jul 21. PMID 25049271, Free PMC Article
  3. Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture. Ganguly S, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949706, Free PMC Article
  4. Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility. Loiseau P, et al. Development, 2010 Aug. PMID 20630947, Free PMC Article
  5. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule-based movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein interacting with APP tail-1
Names
CG10695-PA
CG10695-PB
CG10695-PC
Pat1-PA
Pat1-PB
Pat1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6590776..6596954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132100.5 → NP_572328.1  protein interacting with APP tail-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3Y7
    Related
    FBpp0070906
    Conserved Domains (4) summary
    sd00006
    Location:518 → 546
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:517 → 553
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:516 → 590
    TPR_12; Tetratricopeptide repeat
    cl10012
    Location:53 → 110
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  2. NM_001272357.2 → NP_001259286.1  protein interacting with APP tail-1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3Y7
    Conserved Domains (4) summary
    sd00006
    Location:518 → 546
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:517 → 553
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:516 → 590
    TPR_12; Tetratricopeptide repeat
    cl10012
    Location:53 → 110
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  3. NM_001272356.2 → NP_001259285.1  protein interacting with APP tail-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259285.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGT5
    Conserved Domains (4) summary
    sd00006
    Location:518 → 546
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:517 → 553
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:516 → 590
    TPR_12; Tetratricopeptide repeat
    cl10012
    Location:53 → 110
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGT5 M9PGT5
Q9W3Y7 Q9W3Y7

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