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APC7 Anaphase Promoting Complex subunit 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31594, updated on 4-Jan-2025

Summary

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Official Symbol
APC7provided by FlyBase
Official Full Name
Anaphase Promoting Complex subunit 7provided by FlyBase
Primary source
FLYBASE:FBgn0029879
Locus tag
Dmel_CG14444
See related
AllianceGenome:FB:FBgn0029879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Apc7; CG14444; Dmel\CG14444
Summary
Involved in positive regulation of mitotic metaphase/anaphase transition. Part of anaphase-promoting complex. Is expressed in organism. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See APC7 in Genome Data Viewer
Location:
6C1-6C1; 1-18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6597088..6599699)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6491121..6493732)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43832 Neighboring gene uncharacterized protein Neighboring gene Protein interacting with APP tail-1 Neighboring gene pickled eggs Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster. Magwire MM, et al. PLoS Genet, 2012. PMID 23166512, Free PMC Article
  2. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. Pál M, et al. J Cell Sci, 2007 Sep 15. PMID 17878237
  3. The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Pines MK, et al. Development, 2010 Mar. PMID 20150280, Free PMC Article
  4. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article
  5. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
anaphase promoting complex subunit 7
Names
APC7-PA
APC7-PB
CG14444-PA
CG14444-PB
anaphase promoting complex 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6597088..6599699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132101.4 → NP_572329.3  anaphase promoting complex subunit 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572329.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T020, Q9W3Y6
    Related
    FBpp0070907
    Conserved Domains (2) summary
    sd00006
    Location:321 → 349
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:321 → 386
    TPR_11; TPR repeat

  2. NM_167079.2 → NP_727101.1  anaphase promoting complex subunit 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRQ6, Q8T020
    Related
    FBpp0070908
    Conserved Domains (4) summary
    COG0457
    Location:177 → 438
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00008
    Location:199 → 227
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:234 → 262
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:406 → 438
    TPR_1; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRQ6 Q8IRQ6
Q8T020 Q8T020
Q9W3Y6 Q9W3Y6

Gene LinkOut

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