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pigs pickled eggs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31596, updated on 4-Jan-2025

Summary

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Official Symbol
pigsprovided by FlyBase
Official Full Name
pickled eggsprovided by FlyBase
Primary source
FLYBASE:FBgn0029881
Locus tag
Dmel_CG3973
See related
AllianceGenome:FB:FBgn0029881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3973; Dmel\CG3973; pig
Summary
Predicted to enable actin filament binding activity. Involved in follicle cell of egg chamber stalk formation and negative regulation of Notch signaling pathway. Colocalizes with actin cytoskeleton and cytoplasmic microtubule. Is expressed in adepithelial cell of wing disc and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 41. Orthologous to several human genes including GAS2L1 (growth arrest specific 2 like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pigs in Genome Data Viewer
Location:
6C1-6C3; 1-18 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6600062..6653015)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6494095..6547048)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43832 Neighboring gene Protein interacting with APP tail-1 Neighboring gene Anaphase Promoting Complex subunit 7 Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cdc7 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation. Girdler GC, et al. J Cell Sci, 2016 Jan 1. PMID 26585311, Free PMC Article
  2. FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Moschetti R, et al. Mol Genet Genomics, 2004 May. PMID 15060822
  3. Structured inquiry-based learning: Drosophila GAL4 enhancer trap characterization in an undergraduate laboratory course. Dunne CR, et al. PLoS Biol, 2014 Dec. PMID 25549104, Free PMC Article
  4. Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages. Freda PJ, et al. J Exp Biol, 2022 Jun 1. PMID 35578907
  5. The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families. Röper K, et al. J Cell Sci, 2002 Nov 15. PMID 12376554

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber stalk formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pickled eggs
Names
CG3973-PA
CG3973-PB
CG3973-PC
pigs-PA
pigs-PB
pigs-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6600062..6653015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298020.1 → NP_001284949.1  pickled eggs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284949.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TD5, Q9W3Y4
    Conserved Domains (2) summary
    cd00014
    Location:22 → 159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:258 → 325
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  2. NM_132103.3 → NP_572331.2  pickled eggs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572331.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TD5, Q9W3Y4
    Related
    FBpp0070909
    Conserved Domains (2) summary
    cd00014
    Location:22 → 159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:258 → 325
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  3. NM_001258621.2 → NP_001245550.1  pickled eggs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245550.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TD5, Q9W3Y4
    Conserved Domains (2) summary
    cd00014
    Location:22 → 159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:258 → 325
    GAS2; Growth-Arrest-Specific Protein 2 Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3Y4.2 Q9W3Y4

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