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Trak1 trafficking kinesin protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316085, updated on 4-Jan-2025

Summary

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Official Symbol
Trak1provided by RGD
Official Full Name
trafficking kinesin protein 1provided by RGD
Primary source
RGD:1307844
See related
EnsemblRapid:ENSRNOG00000019262 AllianceGenome:RGD:1307844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OIP106; RGD1307844
Summary
Enables TPR domain binding activity. Involved in axonal transport of mitochondrion; dendrite morphogenesis; and positive regulation of axonogenesis. Located in axonal growth cone; dendrite; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 68. Orthologous to human TRAK1 (trafficking kinesin protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 204.9), Muscle (RPKM 116.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trak1 in Genome Data Viewer
Location:
8q32
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (129861967..130016870)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (120984445..121139357)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (129946596..130106382)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene unc-51 like kinase 4 Neighboring gene uncharacterized LOC134480250 Neighboring gene uncharacterized LOC120094299 Neighboring gene uncharacterized LOC120094301 Neighboring gene uncharacterized LOC120094300 Neighboring gene uncharacterized LOC120094388 Neighboring gene cholecystokinin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy. Wu H, et al. Mol Neurobiol, 2021 Mar. PMID 33119838
  2. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. Loss O, et al. J Neurosci Res, 2015 Jul. PMID 25653102
  3. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. Webber E, et al. J Mol Biol, 2008 Oct 10. PMID 18675823, Free PMC Article
  4. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, et al. Neuron, 2013 Feb 6. PMID 23395375
  5. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Gilbert SL, et al. Nat Genet, 2006 Feb. PMID 16380713

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
    Title: TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables TPR domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal transport of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trafficking kinesin-binding protein 1
Names
trafficking protein, kinesin binding 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134565.2 → NP_001128037.1  trafficking kinesin-binding protein 1

    See identical proteins and their annotated locations for NP_001128037.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZSR6, A0A8I6AI05, A6I434
    Related
    ENSRNOP00000026106.7, ENSRNOT00000026106.7
    Conserved Domains (4) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:421 → 580
    Milton; Kinesin associated protein
    cl12013
    Location:132 → 345
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:263 → 355
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    129861967..130016870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081651.2 → XP_038937579.1  trafficking kinesin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A6I435
    Related
    ENSRNOP00000092949.1, ENSRNOT00000101633.2
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:308 → 477
    Milton; Kinesin associated protein

  2. XM_039081652.2 → XP_038937580.1  trafficking kinesin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:308 → 477
    Milton; Kinesin associated protein

  3. XM_039081653.2 → XP_038937581.1  trafficking kinesin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:308 → 477
    Milton; Kinesin associated protein

  4. XM_039081645.2 → XP_038937573.1  trafficking kinesin-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AI05
    Conserved Domains (2) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:411 → 580
    Milton; Kinesin associated protein

  5. XM_039081650.2 → XP_038937578.1  trafficking kinesin-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AI05
    Conserved Domains (2) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:411 → 580
    Milton; Kinesin associated protein

  6. XM_006244101.5 → XP_006244163.1  trafficking kinesin-binding protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AI05
    Conserved Domains (4) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:421 → 580
    Milton; Kinesin associated protein
    cl12013
    Location:132 → 345
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:263 → 355
    ATP-synt_B; ATP synthase B/B' CF(0)

  7. XM_039081656.2 → XP_038937584.1  trafficking kinesin-binding protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5Y2D1
    Conserved Domains (2) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:411 → 580
    Milton; Kinesin associated protein

  8. XM_039081658.2 → XP_038937586.1  trafficking kinesin-binding protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I5Y2D1
    Related
    ENSRNOP00000078079.1, ENSRNOT00000112022.2
    Conserved Domains (2) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:411 → 580
    Milton; Kinesin associated protein

  9. XM_039081659.2 → XP_038937587.1  trafficking kinesin-binding protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I5Y2D1
    Conserved Domains (2) summary
    pfam04849
    Location:49 → 352
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:411 → 580
    Milton; Kinesin associated protein

  10. XM_039081654.2 → XP_038937582.1  trafficking kinesin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:308 → 477
    Milton; Kinesin associated protein

  11. XM_039081655.2 → XP_038937583.1  trafficking kinesin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:1 → 249
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:308 → 477
    Milton; Kinesin associated protein

  12. XM_063265659.1 → XP_063121729.1  trafficking kinesin-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A6I435

  13. XM_039081648.2 → XP_038937576.1  trafficking kinesin-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:45 → 302
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:361 → 530
    Milton; Kinesin associated protein

  14. XM_006244102.5 → XP_006244164.1  trafficking kinesin-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A6I435
    Related
    ENSRNOP00000088532.2, ENSRNOT00000118223.2
    Conserved Domains (4) summary
    pfam12448
    Location:371 → 530
    Milton; Kinesin associated protein
    pfam14662
    Location:74 → 290
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl12013
    Location:82 → 295
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:213 → 305
    ATP-synt_B; ATP synthase B/B' CF(0)

  15. XM_008766680.4 → XP_008764902.2  trafficking kinesin-binding protein 1 isoform X10

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:45 → 302
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:361 → 530
    Milton; Kinesin associated protein

  16. XM_039081646.2 → XP_038937574.1  trafficking kinesin-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A6I435
    Conserved Domains (2) summary
    pfam04849
    Location:85 → 342
    HAP1_N; HAP1 N-terminal conserved region
    pfam12448
    Location:401 → 570
    Milton; Kinesin associated protein

  17. XM_063265661.1 → XP_063121731.1  trafficking kinesin-binding protein 1 isoform X14

    UniProtKB/TrEMBL
    A6I435
    Related
    ENSRNOP00000099413.1, ENSRNOT00000168194.1

  18. XM_063265660.1 → XP_063121730.1  trafficking kinesin-binding protein 1 isoform X9

    UniProtKB/TrEMBL
    A6I435

RNA

  1. XR_010053987.1 RNA Sequence

  2. XR_010053988.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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