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sov small ovary [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31615, updated on 4-Jan-2025

Summary

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Official Symbol
sovprovided by FlyBase
Official Full Name
small ovaryprovided by FlyBase
Primary source
FLYBASE:FBgn0287725
Locus tag
Dmel_CG14438
See related
AllianceGenome:FB:FBgn0287725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14438; Dmel\CG14438; EM25; fs(1)A1304; fs(1)M105; l(1)6Dc; l(1)EA42; l(1)EM25; Sov
Summary
Involved in transposable element silencing by piRNA-mediated heterochromatin formation. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; germarium region 1; germline cell; and somatic cell of ovariole. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See sov in Genome Data Viewer
Location:
6C12-6C13; 1-18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6756322..6770712)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6650355..6664745)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44895 Neighboring gene long non-coding RNA:CR44964 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43496 Neighboring gene Coenzyme Q7 Neighboring gene shifted Neighboring gene C3G guanyl-nucleotide exchange factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. fs(1)A1304(1) is a 5' UTR deletion of the essential gene small ovary in Drosophila. Hammond M, et al. MicroPubl Biol, 2020 May 6. PMID 32550484, Free PMC Article
  2. Genetic characterization of small ovaries, a gene required in the soma for the development of the Drosophila ovary and the female germline. Wayne S, et al. Genetics, 1995 Mar. PMID 7768440, Free PMC Article
  3. Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Benner L, et al. Genetics, 2019 Nov. PMID 31558581, Free PMC Article
  4. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Andreev VI, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35173350, Free PMC Article
  5. centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis. Ryder PV, et al. J Cell Biol, 2020 Dec 7. PMID 33196763, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 6757291-6758456 mobile_element_type = transposon:1360{}76
  • Loc: 6770583-6770641 mobile_element_type = transposon:FB{}3535

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ovary
Names
CG14438-PA
CG14438-PB
CG14438-PC
female sterile (1) A1304
female sterile(1)M105
lethal (1) 6Dc
sov-PA
sov-PB
sov-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6756322..6770712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132120.2 → NP_572348.1  small ovary, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572348.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3W6
    Related
    FBpp0070922
    Conserved Domains (1) summary
    pfam16031
    Location:2032 → 2077
    TonB_N; TonB N-terminal region

  2. NM_167090.2 → NP_727123.1  small ovary, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3W6
    Related
    FBpp0070923
    Conserved Domains (1) summary
    pfam16031
    Location:2032 → 2077
    TonB_N; TonB N-terminal region

  3. NM_001298033.1 → NP_001284962.1  small ovary, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3W6
    Conserved Domains (1) summary
    pfam16031
    Location:2032 → 2077
    TonB_N; TonB N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3W6 Q9W3W6

Gene LinkOut

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