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nonC no-on-and-no-off transient C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31625, updated on 9-Dec-2024

Summary

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Official Symbol
nonCprovided by FlyBase
Official Full Name
no-on-and-no-off transient Cprovided by FlyBase
Primary source
FLYBASE:FBgn0263968
Locus tag
Dmel_CG32743
See related
AllianceGenome:FB:FBgn0263968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.24; anon-WO0170980.133; CG32743; CG4549; CG4555; clone 1.24; Dmel\CG32743; dSmg1; rst(1a)cyr; Smg; smg1; Smg1; SMG1
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including neuromuscular synaptic transmission; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and synaptic vesicle transport. Predicted to be part of TOR complex. Predicted to be active in cytoplasm and nucleus. Is expressed in peripodial epithelium of eye disc. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See nonC in Genome Data Viewer
Location:
6D3-6D4; 1-18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6824496..6838122)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6718529..6732155)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene xiantuan Neighboring gene Ataxin 1 Neighboring gene muscarinic Acetylcholine Receptor, C-type Neighboring gene uncharacterized protein Neighboring gene TATA element modulatory factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Chen Z, et al. Genetics, 2005 Sep. PMID 15965240, Free PMC Article
  2. Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Chen Z, et al. Insect Mol Biol, 2006 Apr. PMID 16640728
  3. In search of proteins that are important for synaptic functions in Drosophila visual system. Kim E, et al. J Neurogenet, 2012 Jun. PMID 22283835
  4. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Nelson JO, et al. Genetics, 2018 Aug. PMID 29903866, Free PMC Article
  5. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Song YH, et al. Curr Biol, 2004 Aug 10. PMID 15296752

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. maintains synapse architecture and synaptic vesicle cycling
    Title: The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.
  2. Results show that two nonsense alleles of the ortholog of Smg1 do not affect nonsense-mediated mRNA decay.
    Title: Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster.
  3. RNAi experiments confirm that cyromazine resistance can be achieved by knocking down CG32743.
    Title: Positional cloning of a cyromazine resistance gene in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of TOR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
no-on-and-no-off transient C
Names
CG32743-PA
CG32743-PB
FRAP-related
Smg1
no on or off transient C
nonC-PA
nonC-PB
resistance 1a cyromazine
NP_001284967.1
NP_727132.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6824496..6838122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298038.1 → NP_001284967.1  no-on-and-no-off transient C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP14, Q70PP2, Q9W3V6
    UniProtKB/TrEMBL
    X2JDZ8
    Conserved Domains (4) summary
    cd05170
    Location:1894 → 2196
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3189 → 3217
    FATC; FATC domain
    pfam08771
    Location:1738 → 1845
    Rapamycin_bind; Rapamycin binding domain
    pfam15785
    Location:571 → 1140
    SMG1; Serine/threonine-protein kinase smg-1

  2. NM_167095.3 → NP_727132.1  no-on-and-no-off transient C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727132.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP14, Q70PP2, Q9W3V6
    UniProtKB/TrEMBL
    X2JDZ8
    Related
    FBpp0070933
    Conserved Domains (4) summary
    cd05170
    Location:1894 → 2196
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:3189 → 3217
    FATC; FATC domain
    pfam08771
    Location:1738 → 1845
    Rapamycin_bind; Rapamycin binding domain
    pfam15785
    Location:571 → 1140
    SMG1; Serine/threonine-protein kinase smg-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70PP2.2 Q70PP2
X2JDZ8 X2JDZ8

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