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Tmf TATA element modulatory factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31629, updated on 9-Dec-2024

Summary

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Official Symbol
Tmfprovided by FlyBase
Official Full Name
TATA element modulatory factorprovided by FlyBase
Primary source
FLYBASE:FBgn0029912
Locus tag
Dmel_CG4557
See related
AllianceGenome:FB:FBgn0029912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF46211; CG4557; Dmel\CG4557; TMF
Summary
Enables cargo receptor activity. Involved in intra-Golgi vesicle-mediated transport and vesicle tethering to Golgi. Is active in trans-Golgi network membrane. Orthologous to human TMF1 (TATA element modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tmf in Genome Data Viewer
Location:
6D5-6D6; 1-18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6844341..6847847)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6738374..6741880)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene no-on-and-no-off transient C Neighboring gene muscarinic Acetylcholine Receptor, C-type Neighboring gene uncharacterized protein Neighboring gene Chitinase 11 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus. Park SY, et al. Curr Biol, 2022 Nov 7. PMID 36103876, Free PMC Article
  2. TMF is a golgin that binds Rab6 and influences Golgi morphology. Fridmann-Sirkis Y, et al. BMC Cell Biol, 2004 May 5. PMID 15128430, Free PMC Article
  3. The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. Long AA, et al. J Cell Sci, 2010 Oct 1. PMID 20826458, Free PMC Article
  4. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
  5. Protein interactions on telomeric retrotransposons in Drosophila. Takács S, et al. Int J Biol Sci, 2012. PMID 22949888, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cargo receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle tethering to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TATA element modulatory factor
Names
CG4557-PA
Tmf-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6844341..6847847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132132.3 → NP_572360.1  TATA element modulatory factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3V2
    Related
    FBpp0070954
    Conserved Domains (3) summary
    pfam07798
    Location:420 → 527
    DUF1640; Protein of unknown function (DUF1640)
    pfam12325
    Location:813 → 918
    TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    pfam12329
    Location:405 → 472
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3V2 Q9W3V2

Gene LinkOut

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