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Nck2 NCK adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316369, updated on 27-Nov-2024

Summary

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Official Symbol
Nck2provided by RGD
Official Full Name
NCK adaptor protein 2provided by RGD
Primary source
RGD:1305965
See related
EnsemblRapid:ENSRNOG00000017155 AllianceGenome:RGD:1305965
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including phosphotyrosine residue binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in postsynaptic density. Orthologous to human NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 99.4), Lung (RPKM 93.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nck2 in Genome Data Viewer
Location:
9q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53206006..53332417)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (45713979..45840330)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50246767..50373307)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 13 Neighboring gene U2 spliceosomal RNA Neighboring gene golgi phosphoprotein 3-like, pseudogene 1 Neighboring gene ECRG4 augurin precursor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Guan S, et al. Mol Cell Biol, 2007 Sep. PMID 17591694, Free PMC Article
  2. Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation. Kebache S, et al. J Biol Chem, 2004 Mar 5. PMID 14676213
  3. The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Bladt F, et al. Mol Cell Biol, 2003 Jul. PMID 12808099, Free PMC Article
  4. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. Van Impe K, et al. J Biol Chem, 2003 May 16. PMID 12637565
  5. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Gil D, et al. Cell, 2002 Jun 28. PMID 12110186

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that Nckbeta maintains paxillin stability during neuritogenesis.
    Title: Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendritic spine development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immunological synapse formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoplasmic protein NCK2
Names
non-catalytic region of tyrosine kinase adaptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108216.1 → NP_001101686.1  cytoplasmic protein NCK2

    See identical proteins and their annotated locations for NP_001101686.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    A6INR5, D4A3M8
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    53206006..53332417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244825.5 → XP_006244887.1  cytoplasmic protein NCK2 isoform X1

    See identical proteins and their annotated locations for XP_006244887.1

    UniProtKB/TrEMBL
    A6INR5, D4A3M8
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

  2. XM_063267164.1 → XP_063123234.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A6INR5, D4A3M8

  3. XM_063267163.1 → XP_063123233.1  cytoplasmic protein NCK2 isoform X1

    UniProtKB/TrEMBL
    A6INR5, D4A3M8

  4. XM_008767035.4 → XP_008765257.1  cytoplasmic protein NCK2 isoform X1

    See identical proteins and their annotated locations for XP_008765257.1

    UniProtKB/TrEMBL
    A6INR5, D4A3M8
    Related
    ENSRNOP00000023029.4, ENSRNOT00000023029.9
    Conserved Domains (4) summary
    cd10409
    Location:283 → 380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:2 → 59
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114 → 168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198 → 256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
Nucleotide Protein Strain
Heading Accession and Version

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