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Setd3 SET domain containing 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31638, updated on 9-Dec-2024

Summary

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Official Symbol
Setd3provided by FlyBase
Official Full Name
SET domain containing 3provided by FlyBase
Primary source
FLYBASE:FBgn0052732
Locus tag
Dmel_CG32732
See related
AllianceGenome:FB:FBgn0052732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12542; CG3042; CG32732; Dmel\CG32732; dSETD3; SETD3
Summary
Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm and nucleus. Is expressed in adult head and spermatozoon. Orthologous to human SETD3 (SET domain containing 3, actin N3(tau)-histidine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Setd3 in Genome Data Viewer
Location:
6E3-6E4; 1-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6958032..6968750, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6852065..6862783, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic characterization of SETD3 knockout Drosophila. Tiebe M, et al. PLoS One, 2018. PMID 30067821, Free PMC Article
  2. SETD3 protein is the actin-specific histidine N-methyltransferase. Kwiatkowski S, et al. Elife, 2018 Dec 11. PMID 30526847, Free PMC Article
  3. Multilocus patterns of nucleotide variability and the demographic and selection history of Drosophila melanogaster populations. Haddrill PR, et al. Genome Res, 2005 Jun. PMID 15930491, Free PMC Article
  4. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
  5. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, et al. Genes Dev, 2004 Jun 1. PMID 15145825, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-L-histidine N-tele-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-L-histidine N-tele-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-L-histidine N-tele-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin modification IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-histidine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SET domain containing 3
Names
CG32732-PA
Setd3-PA
NP_727144.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6958032..6968750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167100.3 → NP_727144.1  SET domain containing 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727144.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W3U1
    Related
    FBpp0070998
    Conserved Domains (2) summary
    pfam09273
    Location:400 → 524
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:119 → 378
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3U1.2 Q9W3U1

Gene LinkOut

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