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Ica1l islet cell autoantigen 1-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 316432, updated on 27-Nov-2024

Summary

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Official Symbol
Ica1lprovided by RGD
Official Full Name
islet cell autoantigen 1-likeprovided by RGD
Primary source
RGD:735110
See related
EnsemblRapid:ENSRNOG00000017258 AllianceGenome:RGD:735110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle. Predicted to be active in Golgi apparatus. Orthologous to human ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 88.7), Brain (RPKM 63.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ica1l in Genome Data Viewer
Location:
9q31-q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68906148..68964078, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61410959..61469884, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66788094..66848958, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein, pseudogene 3 Neighboring gene family with sequence similarity 117, member B Neighboring gene uncharacterized LOC120094801 Neighboring gene WD repeat domain 12 Neighboring gene calcium responsive transcription factor Neighboring gene basic proline-rich protein-like Neighboring gene neurobeachin-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. He J, et al. J Cell Sci, 2015 Oct 15. PMID 26306493
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
    Title: ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
islet cell autoantigen 1-like protein
Names
Ica69-related protein
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog
islet cell autoantigen 1, 69kDa-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199400.2 → NP_955432.1  islet cell autoantigen 1-like protein

    See identical proteins and their annotated locations for NP_955432.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q6RUG5
    UniProtKB/TrEMBL
    A0A0H2UHX6
    Related
    ENSRNOP00000045103.4, ENSRNOT00000041546.4
    Conserved Domains (2) summary
    pfam04629
    Location:254 → 435
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    68906148..68964078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596464.3 → XP_017451953.1  islet cell autoantigen 1-like protein isoform X7

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Conserved Domains (2) summary
    pfam04629
    Location:255 → 468
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_063267208.1 → XP_063123278.1  islet cell autoantigen 1-like protein isoform X14

  3. XM_063267204.1 → XP_063123274.1  islet cell autoantigen 1-like protein isoform X9

  4. XM_063267211.1 → XP_063123281.1  islet cell autoantigen 1-like protein isoform X18

  5. XM_063267207.1 → XP_063123277.1  islet cell autoantigen 1-like protein isoform X12

  6. XM_063267212.1 → XP_063123282.1  islet cell autoantigen 1-like protein isoform X19

  7. XM_063267210.1 → XP_063123280.1  islet cell autoantigen 1-like protein isoform X17

    UniProtKB/TrEMBL
    A0A8I5XZZ8, A6IPB8

  8. XM_063267209.1 → XP_063123279.1  islet cell autoantigen 1-like protein isoform X15

    UniProtKB/Swiss-Prot
    Q6RUG5

  9. XM_039083635.2 → XP_038939563.1  islet cell autoantigen 1-like protein isoform X7

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Conserved Domains (2) summary
    pfam04629
    Location:255 → 468
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:46 → 248
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_063267206.1 → XP_063123276.1  islet cell autoantigen 1-like protein isoform X11

    Related
    ENSRNOP00000094417.2, ENSRNOT00000094628.2

  11. XM_008767111.3 → XP_008765333.1  islet cell autoantigen 1-like protein isoform X3

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Conserved Domains (2) summary
    pfam04629
    Location:270 → 484
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 264
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_039083634.2 → XP_038939562.1  islet cell autoantigen 1-like protein isoform X2

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Conserved Domains (2) summary
    pfam04629
    Location:277 → 489
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  13. XM_063267203.1 → XP_063123273.1  islet cell autoantigen 1-like protein isoform X8

  14. XM_063267205.1 → XP_063123275.1  islet cell autoantigen 1-like protein isoform X10

  15. XM_063267202.1 → XP_063123272.1  islet cell autoantigen 1-like protein isoform X5

  16. XM_039083637.2 → XP_038939565.1  islet cell autoantigen 1-like protein isoform X20

    Conserved Domains (2) summary
    pfam04629
    Location:326 → 364
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  17. XM_039083636.2 → XP_038939564.1  islet cell autoantigen 1-like protein isoform X16

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Conserved Domains (2) summary
    pfam04629
    Location:277 → 432
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  18. XM_006244999.4 → XP_006245061.1  islet cell autoantigen 1-like protein isoform X13

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Related
    ENSRNOP00000076459.2, ENSRNOT00000119954.2
    Conserved Domains (2) summary
    pfam04629
    Location:276 → 449
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  19. XM_017596461.3 → XP_017451950.1  islet cell autoantigen 1-like protein isoform X6

    UniProtKB/TrEMBL
    A0A0H2UHX6

  20. XM_006244994.4 → XP_006245056.1  islet cell autoantigen 1-like protein isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHX6
    Related
    ENSRNOP00000104337.1, ENSRNOT00000135120.1
    Conserved Domains (2) summary
    pfam04629
    Location:277 → 490
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  21. XM_006244995.4 → XP_006245057.1  islet cell autoantigen 1-like protein isoform X4

    UniProtKB/TrEMBL
    A0A0H2UHX6, A0A8I6AM57
    Conserved Domains (2) summary
    pfam04629
    Location:276 → 474
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:68 → 270
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  22. XM_039083638.2 → XP_038939566.1  islet cell autoantigen 1-like protein isoform X21

    Conserved Domains (2) summary
    pfam04629
    Location:104 → 317
    ICA69; Islet cell autoantigen ICA69, C-terminal domain
    cl12013
    Location:1 → 97
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RUG5.1 GenPept UniProtKB/Swiss-Prot:Q6RUG5

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