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Trip12 thyroid hormone receptor interactor 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316575, updated on 27-Nov-2024

Summary

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Official Symbol
Trip12provided by RGD
Official Full Name
thyroid hormone receptor interactor 12provided by RGD
Primary source
RGD:1306607
See related
EnsemblRapid:ENSRNOG00000016963 AllianceGenome:RGD:1306607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gtl6; TRIP-12
Summary
Predicted to enable nuclear thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including chromatin remodeling; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 540.0), Kidney (RPKM 380.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trip12 in Genome Data Viewer
Location:
9q35
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93364791..93491015, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85916691..86043312, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92305059..92435388, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC120094725 Neighboring gene uncharacterized LOC134480598 Neighboring gene F-box protein 36 Neighboring gene uncharacterized LOC102550706 Neighboring gene uncharacterized LOC120094727 Neighboring gene solute carrier family 16, member 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. Park Y, et al. J Biol Chem, 2009 Jan 16. PMID 19028681
  2. The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. Kajiro M, et al. PLoS One, 2011. PMID 22028794, Free PMC Article
  3. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Chen D, et al. Nature, 2010 Mar 25. PMID 20208519, Free PMC Article
  4. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Park Y, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18627766
  5. An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing. Kweon SM, et al. Mol Cell, 2019 Jun 20. PMID 30982744, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124674, MGC125132

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair-dependent chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterochromatin boundary formation ISO
Inferred from Sequence Orthology
more info
  
involved_in heterochromatin boundary formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIP12
Names
HECT-type E3 ubiquitin transferase TRIP12
TR-interacting protein 12
gene trap locus 6
probable E3 ubiquitin-protein ligase TRIP12
thyroid receptor-interacting protein 12
NP_001026829.2
XP_006245441.1
XP_006245442.1
XP_008765474.1
XP_017451976.1
XP_017451977.1
XP_038939631.1
XP_038939637.1
XP_038939639.1
XP_038939640.1
XP_063123308.1
XP_063123309.1
XP_063123310.1
XP_063123311.1
XP_063123313.1
XP_063123314.1
XP_063123315.1
XP_063123316.1
XP_063123317.1
XP_063123318.1
XP_063123319.1
XP_063123320.1
XP_063123321.1
XP_063123323.1
XP_063123324.1
XP_063123325.1
XP_063123326.1
XP_063123327.1
XP_063123328.1
XP_063123329.1
XP_063123331.1
XP_063123332.1
XP_063123333.1
XP_063123334.1
XP_063123335.1
XP_063123336.1
XP_063123337.1
XP_063123338.1
XP_063123339.1
XP_063123340.1
XP_063123341.1
XP_063123342.1
XP_063123343.1
XP_063123344.1
XP_063123345.1
XP_063123346.1
XP_063123347.1
XP_063123348.1
XP_063123349.1
XP_063123350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031659.4 → NP_001026829.2  E3 ubiquitin-protein ligase TRIP12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    F1LP64, F1LP79, Q497C1, Q5I0I0
    UniProtKB/TrEMBL
    A6JWC9
    Related
    ENSRNOP00000108120.1, ENSRNOT00000151192.1
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1623 → 2023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:767 → 831
    WWE; WWE domain
    pfam03546
    Location:99 → 377
    Treacle; Treacher Collins syndrome protein Treacle

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    93364791..93491015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267250.1 → XP_063123320.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHN4

  2. XM_063267247.1 → XP_063123317.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  3. XM_063267240.1 → XP_063123310.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

  4. XM_063267279.1 → XP_063123349.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

  5. XM_063267267.1 → XP_063123337.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A8L2RBG4

  6. XM_063267280.1 → XP_063123350.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

  7. XM_063267278.1 → XP_063123348.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

  8. XM_063267276.1 → XP_063123346.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

  9. XM_039083712.2 → XP_038939640.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

    UniProtKB/TrEMBL
    A6JWC9
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1591 → 1991
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 803
    WWE; WWE domain
    pfam15229
    Location:11 → 150
    POM121; POM121 family

  10. XM_017596488.3 → XP_017451977.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

    UniProtKB/TrEMBL
    A6JWC9

  11. XM_063267274.1 → XP_063123344.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

  12. XM_039083711.2 → XP_038939639.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

    UniProtKB/TrEMBL
    A6JWC9
    Conserved Domains (4) summary
    COG5064
    Location:447 → 672
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1618 → 2018
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:769 → 830
    WWE; WWE domain
    pfam15229
    Location:11 → 150
    POM121; POM121 family

  13. XM_063267266.1 → XP_063123336.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A8L2RBG4
    Related
    ENSRNOP00000076130.2, ENSRNOT00000093245.3

  14. XM_063267273.1 → XP_063123343.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

  15. XM_063267269.1 → XP_063123339.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

  16. XM_063267262.1 → XP_063123332.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

  17. XM_039083709.2 → XP_038939637.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JU73
    Conserved Domains (3) summary
    COG5064
    Location:460 → 685
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1631 → 2031
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:782 → 843
    WWE; WWE domain

  18. XM_063267258.1 → XP_063123328.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

    Related
    ENSRNOP00000068991.3, ENSRNOT00000079452.3

  19. XM_063267257.1 → XP_063123327.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

  20. XM_063267261.1 → XP_063123331.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

  21. XM_063267259.1 → XP_063123329.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

  22. XM_017596487.3 → XP_017451976.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JU73

  23. XM_063267256.1 → XP_063123326.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

  24. XM_039083703.2 → XP_038939631.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JU73
    Conserved Domains (3) summary
    COG5064
    Location:489 → 714
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00078
    Location:1660 → 2060
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:811 → 872
    WWE; WWE domain

  25. XM_063267253.1 → XP_063123323.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

  26. XM_006245379.5 → XP_006245441.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JU73, A0A8I6AHN4
    Related
    ENSRNOP00000092462.1, ENSRNOT00000107698.2
    Conserved Domains (3) summary
    smart00119
    Location:1683 → 2061
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1665 → 2065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808 → 873
    WWE; WWE domain

  27. XM_063267243.1 → XP_063123313.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  28. XM_006245380.5 → XP_006245442.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JU73
    Conserved Domains (3) summary
    smart00119
    Location:1679 → 2057
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1661 → 2061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808 → 874
    WWE; WWE domain

  29. XM_063267251.1 → XP_063123321.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

  30. XM_008767252.4 → XP_008765474.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    See identical proteins and their annotated locations for XP_008765474.1

    UniProtKB/TrEMBL
    A0A0G2JU73
    Conserved Domains (3) summary
    smart00119
    Location:1687 → 2065
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1669 → 2069
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808 → 874
    WWE; WWE domain

  31. XM_063267268.1 → XP_063123338.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A8L2RBG4

  32. XM_063267241.1 → XP_063123311.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

  33. XM_063267272.1 → XP_063123342.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

    UniProtKB/Swiss-Prot
    F1LP64, F1LP79, Q497C1, Q5I0I0

  34. XM_063267264.1 → XP_063123334.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

  35. XM_063267254.1 → XP_063123324.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    Related
    ENSRNOP00000104101.1, ENSRNOT00000163092.1

  36. XM_063267249.1 → XP_063123319.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHN4

  37. XM_063267246.1 → XP_063123316.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  38. XM_063267275.1 → XP_063123345.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

  39. XM_063267277.1 → XP_063123347.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

  40. XM_063267271.1 → XP_063123341.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

    UniProtKB/Swiss-Prot
    F1LP64, F1LP79, Q497C1, Q5I0I0

  41. XM_063267265.1 → XP_063123335.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

    UniProtKB/TrEMBL
    A0A8L2RBG4

  42. XM_063267270.1 → XP_063123340.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

  43. XM_063267263.1 → XP_063123333.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

  44. XM_063267255.1 → XP_063123325.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

  45. XM_063267248.1 → XP_063123318.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AHN4

  46. XM_063267244.1 → XP_063123314.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  47. XM_063267238.1 → XP_063123308.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

  48. XM_063267245.1 → XP_063123315.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

  49. XM_063267239.1 → XP_063123309.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LP64.1 GenPept UniProtKB/Swiss-Prot:F1LP64

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