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Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316611, updated on 27-Nov-2024

Summary

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Official Symbol
Agap1provided by RGD
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by RGD
Primary source
RGD:1309244
See related
EnsemblRapid:ENSRNOG00000019476 AllianceGenome:RGD:1309244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centg2
Summary
Predicted to enable GTPase activator activity; GTPase activity; and phospholipid binding activity. Involved in regulation of modification of postsynaptic structure. Is active in postsynaptic endosome. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 97.6), Lung (RPKM 88.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Agap1 in Genome Data Viewer
Location:
9q35-q36
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (97487382..97922870)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (90039720..90475196)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (96718901..97034400)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554475 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene uncharacterized LOC120094807 Neighboring gene uncharacterized LOC134480609 Neighboring gene uncharacterized LOC102554789 Neighboring gene gastrulation brain homeobox 2 Neighboring gene ankyrin repeat and SOCS box-containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. Bendor J, et al. EMBO J, 2010 Aug 18. PMID 20664521, Free PMC Article
  2. A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family. Eberth A, et al. Biochem J, 2009 Jan 1. PMID 18954304
  3. The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Arnold M, et al. Front Cell Neurosci, 2016. PMID 27713690, Free PMC Article
  4. AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase. Meurer S, et al. J Biol Chem, 2004 Nov 19. PMID 15381706
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction with AGAP1 and activity of adaptor protein 3 were required for the endocytic recycling of M5 muscarinic receptor in neurons.
    Title: AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
  2. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase
    Title: AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
Names
centaurin, gamma 2
NP_001101700.2
NP_001388522.1
XP_006245464.2
XP_017451979.1
XP_017451982.1
XP_038939672.1
XP_038939674.1
XP_038939679.1
XP_038939680.1
XP_063123367.1
XP_063123368.1
XP_063123369.1
XP_063123370.1
XP_063123371.1
XP_063123372.1
XP_063123373.1
XP_063123374.1
XP_063123375.1
XP_063123376.1
XP_063123377.1
XP_063123378.1
XP_063123379.1
XP_063123380.1
XP_063123381.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108230.2 → NP_001101700.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000060109.2, ENSRNOT00000065720.3

  2. NM_001401593.1 → NP_001388522.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    97487382..97922870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267308.1 → XP_063123378.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X17

  2. XM_063267307.1 → XP_063123377.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X16

    Related
    ENSRNOP00000074469.2, ENSRNOT00000088192.3

  3. XM_063267311.1 → XP_063123381.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X20

    Related
    ENSRNOP00000108422.1, ENSRNOT00000137621.1

  4. XM_063267309.1 → XP_063123379.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X18

    Related
    ENSRNOP00000104606.1, ENSRNOT00000128951.1

  5. XM_063267310.1 → XP_063123380.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X19

  6. XM_039083751.2 → XP_038939679.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0G2K847
    Conserved Domains (5) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:344 → 539
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:680 → 708
    ANK; ANK repeat [structural motif]
    cd08853
    Location:556 → 664
    ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
    pfam12796
    Location:683 → 773
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_039083752.2 → XP_038939680.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A0G2K847
    Conserved Domains (5) summary
    cd04103
    Location:72 → 229
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:344 → 485
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:626 → 654
    ANK; ANK repeat [structural motif]
    cd08853
    Location:502 → 610
    ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
    pfam12796
    Location:629 → 719
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_017596490.3 → XP_017451979.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1

  9. XM_063267298.1 → XP_063123368.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X3

  10. XM_063267299.1 → XP_063123369.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X4

    Related
    ENSRNOP00000108259.1, ENSRNOT00000163080.1

  11. XM_039083744.2 → XP_038939672.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I6AWZ3
    Conserved Domains (5) summary
    cd04103
    Location:561 → 722
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:837 → 1031
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:1172 → 1200
    ANK; ANK repeat [structural motif]
    cd08853
    Location:1048 → 1156
    ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
    pfam12796
    Location:1175 → 1265
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_017596493.3 → XP_017451982.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5

  13. XM_006245402.5 → XP_006245464.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X8

    Related
    ENSRNOP00000086357.2, ENSRNOT00000104807.2
    Conserved Domains (8) summary
    cd04103
    Location:561 → 722
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00173
    Location:562 → 728
    RAS; Ras subfamily of RAS small GTPases
    cd00204
    Location:1199 → 1288
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:837 → 1058
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:1001 → 1053
    PH; PH domain
    pfam01412
    Location:1077 → 1191
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:1202 → 1292
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1199 → 1227
    ANK; ANK repeat [structural motif]

  14. XM_063267303.1 → XP_063123373.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X10

  15. XM_039083746.2 → XP_038939674.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8I6GDZ1
    Conserved Domains (5) summary
    cd04103
    Location:561 → 722
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd01250
    Location:837 → 978
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    sd00045
    Location:1119 → 1147
    ANK; ANK repeat [structural motif]
    cd08853
    Location:995 → 1103
    ArfGap_AGAP2; ArfGAP with GTPase domain, ANK repeat and PH domain 2
    pfam12796
    Location:1122 → 1212
    Ank_2; Ankyrin repeats (3 copies)

  16. XM_063267297.1 → XP_063123367.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X2

  17. XM_063267304.1 → XP_063123374.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X12

  18. XM_063267306.1 → XP_063123376.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X15

  19. XM_063267302.1 → XP_063123372.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X9

  20. XM_063267305.1 → XP_063123375.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X13

  21. XM_063267300.1 → XP_063123370.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6

    Related
    ENSRNOP00000093401.2, ENSRNOT00000105657.2

  22. XM_063267301.1 → XP_063123371.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X7

    Related
    ENSRNOP00000085146.2, ENSRNOT00000107897.2
Nucleotide Protein Strain
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