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CG2059 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31663, updated on 4-Jan-2025

Summary

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Official Symbol
CG2059provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0029942
Locus tag
Dmel_CG2059
See related
AllianceGenome:FB:FBgn0029942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2059
Summary
Enables carboxylesterase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ABHD11 (abhydrolase domain containing 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG2059 in Genome Data Viewer
Location:
7B1-7B1; 1-20 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7286358..7288117)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7180391..7182150)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32730 Neighboring gene long non-coding RNA:CR44357 Neighboring gene Chronophage Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unc-119 Neighboring gene brinker

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of gene conversion associated with a selective sweep in Drosophila melanogaster. Glinka S, et al. Mol Biol Evol, 2006 Oct. PMID 16868022
  2. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
  3. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
  4. Genomic regulatory blocks underlie extensive microsynteny conservation in insects. Engström PG, et al. Genome Res, 2007 Dec. PMID 17989259, Free PMC Article
  5. A journey into the world of insect lipid metabolism. Toprak U, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32335968

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2059-PA
CG2059-PB
NP_001188553.1
NP_572388.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7286358..7288117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201624.1 → NP_001188553.1  uncharacterized protein Dmel_CG2059, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E5L2, Q0E5M5, Q0E5N0, Q9W3R8
    Conserved Domains (3) summary
    PRK10673
    Location:38 → 305
    PRK10673; acyl-CoA esterase; Provisional
    pfam12695
    Location:54 → 151
    Abhydrolase_5; Alpha/beta hydrolase family
    cl21494
    Location:253 → 287
    Abhydrolase; alpha/beta hydrolases

  2. NM_132160.3 → NP_572388.1  uncharacterized protein Dmel_CG2059, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E5L2, Q0E5M5, Q0E5N0, Q9W3R8
    Related
    FBpp0071006
    Conserved Domains (3) summary
    PRK10673
    Location:38 → 305
    PRK10673; acyl-CoA esterase; Provisional
    pfam12695
    Location:54 → 151
    Abhydrolase_5; Alpha/beta hydrolase family
    cl21494
    Location:253 → 287
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3R8 Q9W3R8

Gene LinkOut

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