U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RpS6 Ribosomal protein S6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31700, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
RpS6provided by FlyBase
Official Full Name
Ribosomal protein S6provided by FlyBase
Primary source
FLYBASE:FBgn0261592
Locus tag
Dmel_CG10944
See related
AllianceGenome:FB:FBgn0261592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
(Rp)S6; air8; air[8]; anon-WO02059370.61; CG10944; Dmel\CG10944; DS6; hen; l(1)air8; l(1)air[8]; l(1)hen; M(1)7BC; M(1)7C; pp30; Rp S6; rps6; rpS6; Rps6; RPS6; S6; S6e
Summary
A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit biogenesis. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RpS6 in Genome Data Viewer
Location:
7C2-7C2; 1-21 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7899624..7901331, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7793657..7795364, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene p115 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene by S6 Neighboring gene defective proboscis extension response 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Watson KL, et al. Proc Natl Acad Sci U S A, 1992 Dec 1. PMID 1454811, Free PMC Article
  2. Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation? Stewart MJ, et al. Bioessays, 1994 Nov. PMID 7840758
  3. The nucleotide sequence of a cloned cDNA encoding ribosomal protein S6 from Drosophila melanogaster. Spencer TA, et al. Biochim Biophys Acta, 1993 Mar 20. PMID 8448211
  4. An encore for ribosome biogenesis in the control of cell proliferation. Thomas G. Nat Cell Biol, 2000 May. PMID 10806485
  5. Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster. Radimerski T, et al. Biochemistry, 2000 May 16. PMID 10801327

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation TAS
Traceable Author Statement
more info
 PubMed 
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosolic ribosome HDA PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit TAS
Traceable Author Statement
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal protein S6
Names
CG10944-PA
CG10944-PB
RpS6-PA
RpS6-PB
S6 ribosomal protein
hemocytes enlarged
lethal(1)aberrant immune response[8]
lethal-(1)-haemocytes enlarged
lethal-aberrant-immune-response-8
minute
minute (1) 7BC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7899624..7901331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078518.3 → NP_511073.1  ribosomal protein S6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511073.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P29327, Q94993, Q9W3N4
    UniProtKB/TrEMBL
    D2NUH9, H1ZYF1
    Related
    FBpp0071087
    Conserved Domains (1) summary
    cl00931
    Location:1 → 222
    Ribosomal_S6e; Ribosomal protein S6e

  2. NM_167136.2 → NP_727213.1  ribosomal protein S6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TP9
    Related
    FBpp0071088
    Conserved Domains (1) summary
    cl00931
    Location:1 → 191
    Ribosomal_S6e; Ribosomal protein S6e
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29327.1 P29327
Q95TP9 Q95TP9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous