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spidey spidey [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31703, updated on 9-Dec-2024

Summary

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Official Symbol
spideyprovided by FlyBase
Official Full Name
spideyprovided by FlyBase
Primary source
FLYBASE:FBgn0029975
Locus tag
Dmel_CG1444
See related
AllianceGenome:FB:FBgn0029975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1444; Dmel\CG1444; Kar; KAR; KAR[CG1444]
Summary
Predicted to enable very-long-chain 3-oxoacyl-CoA reductase activity. Involved in cellular response to nutrient levels; negative regulation of cell growth; and positive regulation of lipid storage. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See spidey in Genome Data Viewer
Location:
7C2-7C2; 1-21 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7908931..7911885)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7802964..7805918)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene by S6 Neighboring gene defective proboscis extension response 14 Neighboring gene snazarus Neighboring gene hold'em

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, et al. Dev Cell, 2019 Jan 28. PMID 30554999, Free PMC Article
  2. Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. Parvy JP, et al. PLoS Genet, 2012. PMID 22956916, Free PMC Article
  3. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. Cinnamon E, et al. PLoS Genet, 2016 Aug. PMID 27500738, Free PMC Article
  4. Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. Chiang YN, et al. PLoS Genet, 2016 Jun. PMID 27333054, Free PMC Article
  5. BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. Emberly E, et al. PLoS Biol, 2008 Dec 23. PMID 19108610, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-long-chain 3-oxoacyl-CoA reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spidey
Names
CG1444-PA
spidey-PA
NP_572420.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7908931..7911885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132192.3 → NP_572420.1  spidey [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3N1
    Related
    FBpp0071047
    Conserved Domains (2) summary
    PLN02780
    Location:8 → 321
    PLN02780; ketoreductase/ oxidoreductase
    cd05356
    Location:52 → 288
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3N1 Q9W3N1

Gene LinkOut

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