Smox Smad on X [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Smoxprovided by FlyBase
Official Full Name: Smad on Xprovided by FlyBase
Primary source: FLYBASE:FBgn0025800
Locus tag: Dmel_CG2262
See related: AllianceGenome:FB:FBgn0025800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2262; Dmel\CG2262; dSmad; dsmad2; dSmad2; dSMAD2; DSmad2; DSMAD2; l(1)G0348; sad; Sad; Smad; smad2; Smad2; SMAD2; Smad2/3; smox; SmoX; SMOX; ted; tmp
Summary: Enables chromatin DNA binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; imaginal disc-derived wing morphogenesis; and nervous system development. Located in cytosol and nucleus. Part of heteromeric SMAD protein complex. Is expressed in several structures, including embryonic anal pad; embryonic/larval midgut; ganglia; germline cell; and larval muscle cell. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome (multiple); Lynch syndrome; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human SMAD2 (SMAD family member 2) and SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 7D14-7D15; 1-22 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8137041..8142279, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8031074..8036312, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females.
Title: dSmad2 differentially regulates dILP2 and dILP5 in insulin producing and circadian pacemaker cells in unmated adult females.
Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
Title: Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
Tissue-autonomous loss of Smad2 leads to wide wing discs.
Title: Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.
Reduction of the Medea or Smox, corrected both heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
Title: SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.
Smox acts downstream of Sax to prevent spermatogonial over-proliferation in Drosophila.
Title: TGFbeta receptor saxophone non-autonomously regulates germline proliferation in a Smox/dSmad2-dependent manner in Drosophila testis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables co-SMAD binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_positive_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc-derived wing size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heteromeric SMAD protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: smad on X

Names: CG2262-PA; CG2262-PB; Smox-PA; Smox-PB; Smox/dSmad2; sisters against dpp; temporarily deranged

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8137041..8142279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298077.1 → NP_001285006.1 smad on X, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285006.1

Status: REVIEWED

UniProtKB/TrEMBL

O96660, Q9TZQ2

Conserved Domains (2) summary

cd10488
Location:7 → 130

MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs

cd10985
Location:285 → 475

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
NM_078524.4 → NP_511079.1 smad on X, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511079.1

Status: REVIEWED

UniProtKB/TrEMBL

O96660, Q9TZQ2

Related

FBpp0071140

Conserved Domains (2) summary

cd10488
Location:7 → 130

MH1_R-SMAD; N-terminal Mad Homology 1 (MH1) domain of receptor regulated SMADs

cd10985
Location:285 → 475

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3