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Wnk3 WNK lysine deficient protein kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317420, updated on 9-Dec-2024

Summary

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Official Symbol
Wnk3provided by RGD
Official Full Name
WNK lysine deficient protein kinase 3provided by RGD
Primary source
RGD:1563131
See related
EnsemblRapid:ENSRNOG00000002537 AllianceGenome:RGD:1563131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563131
Summary
Predicted to enable molecular condensate scaffold activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of pancreatic juice secretion; regulation of metal ion transport; and regulation of protein localization to plasma membrane. Predicted to act upstream of or within maintenance of blood-brain barrier. Predicted to be located in adherens junction and bicellular tight junction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Prieto syndrome. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 113.1), Brain (RPKM 55.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wnk3 in Genome Data Viewer
Location:
Xq12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23599278..23742290)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (20156260..20299252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (20316081..20459245)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2, ribosome maturation factor Neighboring gene ribosomal protein S12, pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene family with sequence similarity 120 member C Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats. Zhu J, et al. Neuroscience, 2021 Nov 21. PMID 34626749
  2. Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway. Wu D, et al. Exp Neurol, 2020 Oct. PMID 32589890
  3. Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Veríssimo F, et al. Oncogene, 2006 Jul 13. PMID 16501604
  4. LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity. Zhang Z, et al. J Biol Chem, 2013 Apr 26. PMID 23482566, Free PMC Article
  5. WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Zhang W, et al. Am J Physiol Renal Physiol, 2008 Nov. PMID 18768590, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
    Title: WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
  2. Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
    Title: Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
  3. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
    Title: LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in membraneless organelle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of pancreatic juice secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of osmosensory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of regulation of monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase WNK3
NP_001157079.1
NP_001398747.1
XP_006256845.1
XP_008771338.1
XP_008771339.1
XP_008771340.1
XP_017457560.1
XP_038955733.1
XP_038955734.1
XP_063136128.1
XP_063136129.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163607.1 → NP_001157079.1  serine/threonine-protein kinase WNK3 isoform 2

    See identical proteins and their annotated locations for NP_001157079.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474063
    UniProtKB/TrEMBL
    A6KLA2, D4A7Z8
    Related
    ENSRNOP00000042493.3, ENSRNOT00000047444.5
    Conserved Domains (3) summary
    smart00220
    Location:151 → 404
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 462
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. NM_001411818.1 → NP_001398747.1  serine/threonine-protein kinase WNK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A1W2Q671
    Related
    ENSRNOP00000076151.2, ENSRNOT00000093675.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    23599278..23742290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280058.1 → XP_063136128.1  serine/threonine-protein kinase WNK3 isoform X4

  2. XM_039099806.2 → XP_038955734.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q671
    Conserved Domains (2) summary
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 488
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  3. XM_008773116.4 → XP_008771338.1  serine/threonine-protein kinase WNK3 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:151 → 404
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 462
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  4. XM_017602071.3 → XP_017457560.1  serine/threonine-protein kinase WNK3 isoform X3

  5. XM_006256783.5 → XP_006256845.1  serine/threonine-protein kinase WNK3 isoform X1

    See identical proteins and their annotated locations for XP_006256845.1

    UniProtKB/TrEMBL
    A0A1W2Q671
    Conserved Domains (2) summary
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 488
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  6. XM_008773118.4 → XP_008771340.1  serine/threonine-protein kinase WNK3 isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:151 → 404
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 462
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  7. XM_063280059.1 → XP_063136129.1  serine/threonine-protein kinase WNK3 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K2Y2
    Related
    ENSRNOP00000072423.2, ENSRNOT00000082177.3

  8. XM_008773117.4 → XP_008771339.1  serine/threonine-protein kinase WNK3 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:151 → 404
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 462
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  9. XM_039099805.2 → XP_038955733.1  serine/threonine-protein kinase WNK3 isoform X1

    UniProtKB/TrEMBL
    A0A1W2Q671
    Conserved Domains (2) summary
    cd14031
    Location:135 → 409
    STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
    pfam12202
    Location:425 → 488
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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