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nAChRalpha3 nicotinic Acetylcholine Receptor alpha3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31767, updated on 9-Dec-2024

Summary

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Official Symbol
nAChRalpha3provided by FlyBase
Official Full Name
nicotinic Acetylcholine Receptor alpha3provided by FlyBase
Primary source
FLYBASE:FBgn0015519
Locus tag
Dmel_CG2302
See related
AllianceGenome:FB:FBgn0015519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Acr7E; alpha3; CG2302; Da3; Dalpha3; Dalpha3 nAChR; Dmel\CG2302; D[a3]; lincRNA.965; nAChR; nAchRalpha3; nAcRalpha-7E; nACRalpha-7E; nAcRe; nicra3
Summary
Contributes to acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport. Part of acetylcholine-gated channel complex. Is expressed in adult head and lamina monopolar neuron L2. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to several human genes including CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See nAChRalpha3 in Genome Data Viewer
Location:
7E1-7E4; 1-23 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8276200..8367169, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8170233..8261202, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Companion of reaper Neighboring gene long non-coding RNA:CR43695 Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex. Chamaon K, et al. FEBS Lett, 2000 Oct 6. PMID 11024458
  2. The spread of resistance to imidacloprid is restricted by thermotolerance in natural populations of Drosophila melanogaster. Fournier-Level A, et al. Nat Ecol Evol, 2019 Apr. PMID 30886368
  3. Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors. Wu M, et al. PLoS One, 2016. PMID 26828958, Free PMC Article
  4. Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila. Murmu MS, et al. BMC Neurosci, 2011 Oct 24. PMID 22024464, Free PMC Article
  5. How complex is the nicotinic receptor system of insects? Gundelfinger ED. Trends Neurosci, 1992 Jun. PMID 1378663

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinic acetylcholine receptor alpha3
Names
CG2302-PB
CG2302-PC
Dalpha3
drosophila alpha-like subunit 3
nAChRalpha3-PB
nAChRalpha3-PC
nAcRalpha-7E
nicotinic acetylcholine receptor alpha 7E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8276200..8367169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298086.1 → NP_001285015.1  nicotinic acetylcholine receptor alpha3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285015.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18394, Q9W3G6
    Conserved Domains (2) summary
    pfam02931
    Location:26 → 241
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:248 → 359
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_080340.4 → NP_525079.3  nicotinic acetylcholine receptor alpha3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525079.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18394, Q9W3G6
    Conserved Domains (2) summary
    pfam02931
    Location:26 → 241
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:248 → 359
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18394 O18394
O44202 O44202
Q9W3G6 Q9W3G6

Gene LinkOut

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