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nfe2 nuclear factor, erythroid 2 [ Danio rerio (zebrafish) ]

Gene ID: 317765, updated on 12-Jan-2025

Summary

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Official Symbol
nfe2provided by ZNC
Official Full Name
nuclear factor, erythroid 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030124-1
See related
Ensembl:ENSDARG00000020606 AllianceGenome:ZFIN:ZDB-GENE-030124-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Acts upstream of or within several processes, including otic vesicle morphogenesis; regulation of primitive erythrocyte differentiation; and swim bladder inflation. Part of transcription regulator complex. Is expressed in blood; otic placode; otic vesicle; ventral mesenchyme; and ventral mesoderm. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nfe2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (36311494..36320701, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (36212127..36222031, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene chromobox homolog 5 (HP1 alpha homolog, Drosophila) Neighboring gene heterogeneous nuclear ribonucleoprotein A1b Neighboring gene COPI coat complex subunit zeta 1 Neighboring gene zinc finger protein 740b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Rost MS, et al. Blood Adv, 2018 Dec 11. PMID 30504234, Free PMC Article
  2. Establishment of a Bernard-Soulier syndrome model in zebrafish. Lin Q, et al. Haematologica, 2022 Jul 1. PMID 34407604, Free PMC Article
  3. Loss of fibrinogen in zebrafish results in an asymptomatic embryonic hemostatic defect and synthetic lethality with thrombocytopenia. Hu Z, et al. J Thromb Haemost, 2019 Apr. PMID 30663848, Free PMC Article
  4. Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Ramsden R, et al. Redox Biol, 2016 Oct. PMID 27470083, Free PMC Article
  5. Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish. Yang L, et al. J Thromb Haemost, 2022 Aug. PMID 35622056

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otic vesicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IC
Inferred by Curator
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swim bladder inflation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor NF-E2 45 kDa subunit
Names
nuclear factor (erythroid-derived 2), 45 kDa
nuclear factor protein
nuclear factor, erythroid-derived 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175043.2 → NP_778208.1  transcription factor NF-E2 45 kDa subunit

    See identical proteins and their annotated locations for NP_778208.1

    Status: PROVISIONAL

    Source sequence(s)
    AY170917
    UniProtKB/TrEMBL
    Q7ZZR2
    Related
    ENSDARP00000105608.2, ENSDART00000125860.3
    Conserved Domains (1) summary
    cd14720
    Location:310 → 377
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    36311494..36320701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216670.1 → XP_068072771.1  transcription factor NF-E2 45 kDa subunit isoform X1

    UniProtKB/TrEMBL
    A0A8M2B990, F1QWY1

  2. XM_009297037.4 → XP_009295312.1  transcription factor NF-E2 45 kDa subunit isoform X1

    See identical proteins and their annotated locations for XP_009295312.1

    UniProtKB/TrEMBL
    A0A8M2B990, F1QWY1
    Related
    ENSDARP00000002745.4, ENSDART00000014840.6
    Conserved Domains (1) summary
    cd14720
    Location:357 → 424
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

  3. XM_005162369.5 → XP_005162426.1  transcription factor NF-E2 45 kDa subunit isoform X1

    See identical proteins and their annotated locations for XP_005162426.1

    UniProtKB/TrEMBL
    A0A8M2B990, F1QWY1
    Conserved Domains (1) summary
    cd14720
    Location:357 → 424
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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