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MYB MYB proto-oncogene, transcription factor [ Bos taurus (domestic cattle) ]

Gene ID: 317776, updated on 29-Jan-2025

Summary

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Official Symbol
MYBprovided by VGNC
Official Full Name
MYB proto-oncogene, transcription factorprovided by VGNC
Primary source
VGNC:VGNC:31776
See related
BGD:BT11241; Ensembl:ENSBTAG00000012074
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See MYB in Genome Data Viewer
Location:
chromosome: 9
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (73222333..73257774)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 8 family member A1 Neighboring gene HBS1 like translational GTPase Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene cleavage stimulation factor subunit 3-like Neighboring gene Abelson helper integration site 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A spontaneous internal deletion of the c-myb protooncogene enhances transcriptional activation in bovine T lymphoma cells. Ishiguro N, et al. J Biol Chem, 1994 Oct 28. PMID 7929419
  2. Expression of the c-myb proto-oncogene in bovine vascular smooth muscle cells. Brown KE, et al. J Biol Chem, 1992 Mar 5. PMID 1537845
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcriptional activator Myb
Names
C-myb
myb proto-oncogene protein
proto-oncogene c-Myb
v-myb myeloblastosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175050.1 → NP_778220.1  transcriptional activator Myb

    See identical proteins and their annotated locations for NP_778220.1

    Status: PROVISIONAL

    Source sequence(s)
    D26148
    UniProtKB/TrEMBL
    F1N028, Q28080
    Related
    ENSBTAP00070023295.1, ENSBTAT00070039247.1
    Conserved Domains (4) summary
    smart00717
    Location:92 → 140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92 → 138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269 → 313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:317 → 477
    Cmyb_C; C-myb, C-terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    73222333..73257774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005210940.5 → XP_005210997.1  transcriptional activator Myb isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MAD3
    Related
    ENSBTAP00070023287.1, ENSBTAT00070039228.1
    Conserved Domains (4) summary
    pfam00249
    Location:40 → 86
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269 → 313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:518 → 684
    Cmyb_C; C-myb, C-terminal
    cl28544
    Location:89 → 202
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  2. XM_015472868.3 → XP_015328354.1  transcriptional activator Myb isoform X3

    UniProtKB/TrEMBL
    A0A3Q1MAD3
    Conserved Domains (4) summary
    smart00717
    Location:92 → 140
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:92 → 138
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269 → 313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:518 → 683
    Cmyb_C; C-myb, C-terminal

  3. XM_005210945.5 → XP_005211002.1  transcriptional activator Myb isoform X4

    UniProtKB/Swiss-Prot
    P46200
    Related
    ENSBTAP00070023263.1, ENSBTAT00070039173.1
    Conserved Domains (4) summary
    pfam00249
    Location:40 → 86
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam07988
    Location:269 → 313
    LMSTEN; LMSTEN motif
    pfam09316
    Location:401 → 563
    Cmyb_C; C-myb, C-terminal
    cl28544
    Location:89 → 202
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  4. XM_059889592.1 → XP_059745575.1  transcriptional activator Myb isoform X2

    UniProtKB/TrEMBL
    A0A3Q1MAD3
    Related
    ENSBTAP00070023210.1, ENSBTAT00070039085.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46200.1 GenPept UniProtKB/Swiss-Prot:P46200

Gene LinkOut

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