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Es2 Es2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31780, updated on 4-Jan-2025

Summary

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Official Symbol
Es2provided by FlyBase
Official Full Name
Es2provided by FlyBase
Primary source
FLYBASE:FBgn0023506
Locus tag
Dmel_CG1474
See related
AllianceGenome:FB:FBgn0023506
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1474; Dmel\CG1474; es; ES2
Summary
Predicted to be involved in nervous system development. Part of catalytic step 2 spliceosome. Orthologous to human ESS2 (ess-2 splicing factor homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Es2 in Genome Data Viewer
Location:
7E11-7E11; 1-23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8461479..8463349)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8355512..8357382)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sepiapterin reductase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chorion protein a at 7F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. Lindsay EA, et al. Hum Mol Genet, 1998 Apr. PMID 9499415
  2. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Claycomb JM, et al. Dev Cell, 2004 Jan. PMID 14723854
  3. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
  4. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874
  5. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Es2
Names
CG1474-PA
Es2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8461479..8463349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132252.5 → NP_572480.1  Es2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44424, Q8T9F3, Q9W3F2
    UniProtKB/TrEMBL
    B5RIV5
    Related
    FBpp0071145
    Conserved Domains (1) summary
    pfam09751
    Location:47 → 417
    Es2; Nuclear protein Es2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44424.2 O44424

Gene LinkOut

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