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anne anne boleyn [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317815, updated on 4-Jan-2025

Summary

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Official Symbol
anneprovided by FlyBase
Official Full Name
anne boleynprovided by FlyBase
Primary source
FLYBASE:FBgn0052000
Locus tag
Dmel_CG32000
See related
AllianceGenome:FB:FBgn0052000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATP13A2; BcDNA:LD05303; BcDNA:LD19039; BcDNA:SD17880; CG32000; dATP13A2; Dm V-1; Dmel\CG32000
Summary
Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; hereditary spastic paraplegia 78; and primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See anne in Genome Data Viewer
Location:
102A3-102A4; 4-0 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (132220..143123)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (152846..163749)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene pangolin Neighboring gene Ankyrin Neighboring gene long non-coding RNA:CR43956 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein. Dhanushkodi NR, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675288, Free PMC Article
  2. SON protects nascent transcripts from unproductive degradation by counteracting DIP1. Tay ML, et al. PLoS Genet, 2019 Nov. PMID 31730657, Free PMC Article
  3. ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, et al. J Cell Biol, 2019 Jan 7. PMID 30538141, Free PMC Article
  4. Flies with Parkinson's disease. Vanhauwaert R, et al. Exp Neurol, 2015 Dec. PMID 25708988
  5. The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson's Disease. Vos M, et al. Cells, 2021 Mar 6. PMID 33800736, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant alpha-Synuclein.
    Title: ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 135593-135708 mobile_element_type = transposon:INE-1{}4649
  • Loc: 138906-138970 mobile_element_type = transposon:INE-1{}4651
  • Loc: 138971-139934 mobile_element_type = transposon:1360{}4770
  • Loc: 139426-139691 mobile_element_type = transposon:INE-1{}4653
  • Loc: 140103-140151 mobile_element_type = transposon:INE-1{}4655

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables polyamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyamine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
anne boleyn
Names
CG32000-PA
CG32000-PB
CG32000-PC
CG32000-PD
CG32000-PE
CG32000-PF
CG32000-PG
CG32000-PH
CG32000-PI
anne-PA
anne-PB
anne-PC
anne-PD
anne-PE
anne-PF
anne-PG
anne-PH
anne-PI
anneboleyn

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    132220..143123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103379.2 → NP_001096849.1  anne boleyn, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ26
    Conserved Domains (5) summary
    TIGR01657
    Location:173 → 1355
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:381 → 621
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:158 → 291
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:758 → 813
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1087 → 1137
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_205865.2 → NP_995587.1  anne boleyn, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KQN3
    Conserved Domains (5) summary
    TIGR01657
    Location:110 → 1292
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:318 → 558
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:95 → 228
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:695 → 750
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:1024 → 1074
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. NM_166728.2 → NP_726532.1  anne boleyn, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726532.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXV3
    Related
    FBpp0088461
    Conserved Domains (2) summary
    pfam00122
    Location:381 → 621
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:158 → 291
    P5-ATPase; P5-type ATPase cation transporter

  4. NM_166733.2 → NP_726537.1  anne boleyn, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726537.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMA3
    Related
    FBpp0088460
    Conserved Domains (2) summary
    pfam00122
    Location:220 → 460
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:1 → 130
    P5-ATPase; P5-type ATPase cation transporter

  5. NM_166729.2 → NP_726533.1  anne boleyn, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMA7
    Related
    FBpp0088459
    Conserved Domains (2) summary
    pfam00122
    Location:318 → 558
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:95 → 228
    P5-ATPase; P5-type ATPase cation transporter

  6. NM_001272114.1 → NP_001259043.1  anne boleyn, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259043.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MLL1
    Conserved Domains (5) summary
    TIGR01657
    Location:12 → 1194
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:220 → 460
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:1 → 130
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:597 → 652
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:926 → 976
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  7. NM_166730.3 → NP_726534.2  anne boleyn, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726534.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMA6
    Related
    FBpp0088463
    Conserved Domains (5) summary
    TIGR01657
    Location:36 → 1218
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:244 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:21 → 154
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:621 → 676
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:950 → 1000
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  8. NM_166732.3 → NP_726536.2  anne boleyn, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726536.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMA6
    Related
    FBpp0088462
    Conserved Domains (5) summary
    TIGR01657
    Location:36 → 1218
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:244 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:21 → 154
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:621 → 676
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:950 → 1000
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  9. NM_166731.2 → NP_726535.1  anne boleyn, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMA5
    Related
    FBpp0088464
    Conserved Domains (2) summary
    pfam00122
    Location:244 → 484
    E1-E2_ATPase; E1-E2 ATPase
    pfam12409
    Location:21 → 154
    P5-ATPase; P5-type ATPase cation transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ26 A8DZ26
L0MLL1 L0MLL1
Q7KQN3 Q7KQN3
Q8IG91 Q8IG91
Q8IMA3 Q8IMA3
Q8IMA5 Q8IMA5
Q8IMA6 Q8IMA6
Q8IMA7 Q8IMA7
Q8SXV3 Q8SXV3
Q8T0G2 Q8T0G2

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