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ND-MLRQ NADH dehydrogenase (ubiquinone) MLRQ subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317928, updated on 9-Dec-2024

Summary

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Official Symbol
ND-MLRQprovided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) MLRQ subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0052230
Locus tag
Dmel_CG32230
See related
AllianceGenome:FB:FBgn0052230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE56733; BEST:GH04411; CG32230; Dmel\CG32230; NDUFA4; NUML; Q8SYJ2
Summary
Predicted to be part of respiratory chain complex IV. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated) and NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ND-MLRQ in Genome Data Viewer
Location:
80F2-80F2; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23339326..23345936)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23332426..23339036)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha4 Neighboring gene long non-coding RNA:CR46475 Neighboring gene alpha Catenin Neighboring gene mir-4942 stem loop Neighboring gene Argonaute 3 Neighboring gene long non-coding RNA:CR45174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative proteomics analysis of dietary restriction in Drosophila. Gao Y, et al. PLoS One, 2020. PMID 33064752, Free PMC Article
  2. α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Jurado J, et al. J Cell Sci, 2016 Dec 15. PMID 27831494
  3. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
  4. Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq. Aspden JL, et al. Elife, 2014 Aug 21. PMID 25144939, Free PMC Article
  5. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 23339885-23340321 mobile_element_type = transposon:INE-1{}4071
  • Loc: 23344099-23344783 mobile_element_type = transposon:1360{}1160

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) MLRQ subunit
Names
CG32230-PA
CG32230-PB
CG32230-PC
NADH ubiquinone oxidoreductase MLRQ
NADH-ubiquinone oxidoreductase MLRQ subunit
NADH:ubiquinone oxidoreductase MLRQ subunit
ND-MLRQ-PA
ND-MLRQ-PB
ND-MLRQ-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    23339326..23345936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275306.2 → NP_001262235.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262235.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYJ2
    Conserved Domains (1) summary
    pfam06522
    Location:11 → 76
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

  2. NM_168988.3 → NP_730777.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYJ2
    Related
    FBpp0070039
    Conserved Domains (1) summary
    pfam06522
    Location:11 → 76
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

  3. NM_168989.3 → NP_730778.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYJ2
    Related
    FBpp0070040
    Conserved Domains (1) summary
    pfam06522
    Location:11 → 76
    B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYJ2 Q8SYJ2

Gene LinkOut

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