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tut tumorous testis [ Drosophila melanogaster (fruit fly) ]

Gene ID: 317996, updated on 9-Dec-2024

Summary

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Official Symbol
tutprovided by FlyBase
Official Full Name
tumorous testisprovided by FlyBase
Primary source
FLYBASE:FBgn0052364
Locus tag
Dmel_CG32364
See related
AllianceGenome:FB:FBgn0052364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.705; CG32364; Dmel\CG32364; Tut
Summary
Enables RNA binding activity. Involved in male germline stem cell symmetric division and negative regulation of translation. Located in cytoplasm. Is expressed in spermatogonium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tut in Genome Data Viewer
Location:
66B13-66C1; 3-22 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8209577..8210743, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8202677..8203843, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. Chen D, et al. PLoS Genet, 2014 Nov. PMID 25412508, Free PMC Article
  2. A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis. Zhao T, et al. Cell Death Dis, 2022 Sep 2. PMID 36056003, Free PMC Article
  3. Autophagy is required for spermatogonial differentiation in the Drosophila testis. Varga VB, et al. Biol Futur, 2022 Jun. PMID 35672498
  4. The Drosophila LIN54 homolog Mip120 controls two aspects of oogenesis. Cheng MH, et al. Biol Open, 2017 Jul 15. PMID 28522430, Free PMC Article
  5. The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster. Nazario-Toole AE, et al. J Immunol, 2018 Aug 15. PMID 29997126, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in male germline stem cell symmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumorous testis
Names
CG32364-PA
tut-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8209577..8210743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168261.3 → NP_729346.1  tumorous testis [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729346.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V4A4, Q8IQA2
    Related
    FBpp0076443
    Conserved Domains (2) summary
    cd12249
    Location:36 → 115
    RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
    pfam11868
    Location:127 → 169
    DUF3388; Protein of unknown function (DUF3388)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQA2 Q8IQA2

Gene LinkOut

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