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Arv1 ACAT-related protein required for viability 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318031, updated on 4-Jan-2025

Summary

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Official Symbol
Arv1provided by FlyBase
Official Full Name
ACAT-related protein required for viability 1provided by FlyBase
Primary source
FLYBASE:FBgn0052442
Locus tag
Dmel_CG32442
See related
AllianceGenome:FB:FBgn0052442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE62711; BcDNA:RH17480; CG32442; Dmel\CG32442
Summary
Involved in positive regulation of cell division. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Arv1 in Genome Data Viewer
Location:
78D5-78D5; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21528218..21529333, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21521318..21522433, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 12 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43877 Neighboring gene Makorin 1 Neighboring gene pickpocket 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arv1 promotes cell division by recruiting IQGAP1 and myosin to the cleavage furrow. Sundvold H, et al. Cell Cycle, 2016. PMID 27104745, Free PMC Article
  2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
  3. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683
  4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  5. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik JA, et al. Cell, 2010 Jan 8. PMID 20074523

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of plasma membrane sterol distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ACAT-related protein required for viability 1
Names
Arv1-PA
Arv1-PB
Arv1-PC
CG32442-PA
CG32442-PB
CG32442-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21528218..21529333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168920.3 → NP_730651.1  ACAT-related protein required for viability 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYH1
    Related
    FBpp0088739
    Conserved Domains (1) summary
    pfam04161
    Location:8 → 194
    Arv1; Arv1-like family

  2. NM_001144523.3 → NP_001137995.1  ACAT-related protein required for viability 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z097, Q8IGH7
    Conserved Domains (1) summary
    cl21705
    Location:8 → 68
    Arv1; Arv1-like family

  3. NM_168921.3 → NP_730652.1  ACAT-related protein required for viability 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGH7, Q8IPT3
    Related
    FBpp0088738
    Conserved Domains (1) summary
    cl21705
    Location:8 → 68
    Arv1; Arv1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z097 B7Z097
Q8IGH7 Q8IGH7
Q8IPT3 Q8IPT3
Q8SYH1 Q8SYH1

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