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CAH3 Carbonic anhydrase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31804, updated on 4-Jan-2025

Summary

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Official Symbol
CAH3provided by FlyBase
Official Full Name
Carbonic anhydrase 3provided by FlyBase
Primary source
FLYBASE:FBgn0030056
Locus tag
Dmel_CG11284
See related
AllianceGenome:FB:FBgn0030056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11284; CG11285; Dmel\CG11284
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CAH3 in Genome Data Viewer
Location:
8A1-8A2; 1-24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8681252..8688760)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8575285..8582793)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ocelliless Neighboring gene rubicon Neighboring gene Palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized protein Neighboring gene 8-oxoguanine DNA glycosylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae. Aby E, et al. Fly (Austin), 2013 Oct-Dec. PMID 24091420, Free PMC Article
  2. Characterization of Drosophila palmitoyl-protein thioesterase 1. Glaser RL, et al. Gene, 2003 Jul 17. PMID 12909364
  3. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
  4. Cloning of the neurodegeneration gene drop-dead and characterization of additional phenotypes of its mutation. Blumenthal EM. Fly (Austin), 2008 Jul-Aug. PMID 18719404, Free PMC Article
  5. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbonic anhydrase 3
Names
CAH3-PA
CAH3-PB
CAH3-PC
CAH3-PD
CAH3-PE
CG11284-PA
CG11284-PB
CG11284-PC
CG11284-PD
CG11284-PE
NP_001259349.1
NP_001259350.1
NP_001259351.1
NP_001285023.1
NP_572497.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    8681252..8688760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298094.1 → NP_001285023.1  carbonic anhydrase 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3C8
    Conserved Domains (1) summary
    cd00326
    Location:4 → 233
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. NM_132269.3 → NP_572497.1  carbonic anhydrase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572497.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3C8
    Related
    FBpp0071167
    Conserved Domains (1) summary
    cd00326
    Location:4 → 233
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. NM_001272422.1 → NP_001259351.1  carbonic anhydrase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259351.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3C8
    Conserved Domains (1) summary
    cd00326
    Location:4 → 233
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  4. NM_001272421.1 → NP_001259350.1  carbonic anhydrase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259350.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3C8
    Conserved Domains (1) summary
    cd00326
    Location:4 → 233
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  5. NM_001272420.1 → NP_001259349.1  carbonic anhydrase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259349.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W3C8
    Conserved Domains (1) summary
    cd00326
    Location:4 → 233
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W3C8 Q9W3C8

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