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TwdlZ TweedleZ [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318092, updated on 4-Jan-2025

Summary

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Official Symbol
TwdlZprovided by FlyBase
Official Full Name
TweedleZprovided by FlyBase
Primary source
FLYBASE:FBgn0052569
Locus tag
Dmel_CG32569
See related
AllianceGenome:FB:FBgn0052569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32569; Dmel\CG32569; twdlZ
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See TwdlZ in Genome Data Viewer
Location:
15A3-15A3; 1-55 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16738178..16738868)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16632211..16632901)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene gone early Neighboring gene TweedleX Neighboring gene TweedleY Neighboring gene uncharacterized protein Neighboring gene Tweedlealpha Neighboring gene inflated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article
  2. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article
  3. Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle. Cornman RS, et al. Insect Mol Biol, 2009 Oct. PMID 19754739, Free PMC Article
  4. Molecular evolution of Drosophila cuticular protein genes. Cornman RS. PLoS One, 2009 Dec 17. PMID 20019874, Free PMC Article
  5. Flying toward a plastic-free world: Can Drosophila serve as a model organism to develop new strategies of plastic waste management? Pignataro E, et al. Sci Total Environ, 2024 Mar 1. PMID 38199375

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based cuticle ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
TweedleZ
Names
CG32569-PB
TwdlZ-PB
tweedle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16738178..16738868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167541.3 → NP_728018.2  TweedleZ [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728018.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPG8, Q8IR09
    Conserved Domains (1) summary
    pfam03103
    Location:36 → 132
    DUF243; Domain of unknown function (DUF243)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR09 Q8IR09

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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