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CG32847 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318245, updated on 4-Jan-2025

Summary

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Official Symbol
CG32847provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052847
Locus tag
Dmel_CG32847
See related
AllianceGenome:FB:FBgn0052847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG32847
Summary
Predicted to enable ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding activity; and zinc ion binding activity. Predicted to be involved in ERAD pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human RNF185 (ring finger protein 185) and RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG32847 in Genome Data Viewer
Location:
71B5-71B5; 3-42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15121572..15122301)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15114672..15115401)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CTP synthase Neighboring gene antisense RNA:CR43971 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Centrosomal protein 135kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-U42 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. Xu J, et al. PLoS Genet, 2020 Nov. PMID 33137101, Free PMC Article
  2. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
  3. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article
  4. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Dai H, et al. Gene, 2006 Dec 30. PMID 17101240
  5. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32847-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15121572..15122301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168609.2 → NP_730026.1  uncharacterized protein Dmel_CG32847 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQM1
    Related
    FBpp0075392
    Conserved Domains (2) summary
    PLN03208
    Location:4 → 91
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd00162
    Location:17 → 60
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQM1 Q8IQM1

Gene LinkOut

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