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nenya nenya [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318572, updated on 4-Jan-2025

Summary

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Official Symbol
nenyaprovided by FlyBase
Official Full Name
nenyaprovided by FlyBase
Primary source
FLYBASE:FBgn0051053
Locus tag
Dmel_CG31053
See related
AllianceGenome:FB:FBgn0051053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31053; Dmel\CG31053; Nenya
Summary
Predicted to enable SUMO transferase activity and zinc ion binding activity. Involved in positive regulation of meiotic DNA double-strand break formation. Predicted to be located in chromosome. Predicted to be active in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nenya in Genome Data Viewer
Location:
98B6-98B6; 3-94 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27927357..27928174, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23753079..23753896, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR45566 Neighboring gene Ribosomal protein L4 Neighboring gene minotaur Neighboring gene antisense RNA:CR46452 Neighboring gene Nuclear receptor binding SET domain protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
  2. Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. Lake CM, et al. PLoS Genet, 2019 Jan. PMID 30615609, Free PMC Article
  3. Minotaur is critical for primary piRNA biogenesis. Vagin VV, et al. RNA, 2013 Aug. PMID 23788724, Free PMC Article
  4. SnapShot: Meiosis - Prophase I. Láscarez-Lagunas L, et al. Cell, 2020 Jun 11. PMID 32531249
  5. A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster. Hughes SE, et al. G3 (Bethesda), 2024 Apr 3. PMID 38333961, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SUMO transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of meiotic DNA double-strand break formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptonemal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nenya
Names
CG31053-PA
nenya-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27927357..27928174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170357.3 → NP_733236.1  nenya [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733236.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IMM9
    Related
    FBpp0084637
    Conserved Domains (1) summary
    pfam14634
    Location:5 → 49
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IMM9.1 Q8IMM9

Gene LinkOut

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