U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

su(r) suppressor of rudimentary [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31858, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
su(r)provided by FlyBase
Official Full Name
suppressor of rudimentaryprovided by FlyBase
Primary source
FLYBASE:FBgn0086450
Locus tag
Dmel_CG2194
See related
AllianceGenome:FB:FBgn0086450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2194; Dmel\CG2194; Dreg-3; pyd1; Pyd1; Reg-3; Su(r)
Summary
Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See su(r) in Genome Data Viewer
Location:
8D1-8D1; 1-27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9196808..9201820, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9090841..9095853, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 9 Neighboring gene Odorant-binding protein 8a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 6-Azauracil induced phenocopies of rudimentary wing mutants and their suppression by a suppressor mutant of rudimentary in Drosophila melanogaster. Stroman P, et al. Hereditas, 1973. PMID 4197330
  2. A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression. Van Gelder RN, et al. EMBO J, 1996 Apr 1. PMID 8612586, Free PMC Article
  3. Pyrimidine-sensitive drosophila wing mutants: withered (whd), tilt (tt) and dumpy (dp). Stroman P. Hereditas, 1974. PMID 4219020
  4. Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. Nara T, et al. Gene, 2000 Oct 31. PMID 11080587
  5. Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. Zirin J, et al. Genetics, 2020 Apr. PMID 32071193, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clearly null, loss-of-function mutations characterize the truncated wing phenotype of su(r) mutants resulting from substitution of a highly conserved amino acid residue within dihydropyrimidine dehydrogenase.
    Title: Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidine dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydropyrimidine dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables uracil binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in thymine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uracil catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
suppressor of rudimentary
Names
CG2194-PC
dihydropyrimidine dehydrogenase
drosophila rhythmically expressed gene 3
rhythmically expressed gene 3
su(r)-PC
NP_727320.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9196808..9201820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167182.2 → NP_727320.1  suppressor of rudimentary [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4TWT4, Q9W374
    Related
    FBpp0071273
    Conserved Domains (6) summary
    PRK08318
    Location:527 → 1008
    PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated
    PRK11749
    Location:55 → 507
    PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional
    cd02940
    Location:527 → 829
    DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
    pfam13187
    Location:953 → 997
    Fer4_9; 4Fe-4S dicluster domain
    pfam13450
    Location:190 → 234
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam14691
    Location:58 → 170
    Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4TWT4 Q4TWT4
Q94914 Q94914
Q95U76 Q95U76
Q9W374 Q9W374

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous